SCHEMBL25924944

SCHEMBL25924944

CCN1Cc2cc(NC)ccc2C(F)(F)C1

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
L3MBTL3 Q96JM7 2/20 0.36
WEE1 P30291 1/20 0.33
HTR2C P28335 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15787911 0.78 L3MBTL3 (0.51) L3MBTL3HTR2CL3MBTL1
SCHEMBL25924943 0.73 ALDH1A1 (0.34)
SCHEMBL25555965 0.73 HRH3 (0.48) L3MBTL3
SCHEMBL22742692 0.69 WEE1 (0.36) L3MBTL3WEE1
SCHEMBL19241711 0.67 JAK2 (0.38) L3MBTL3L3MBTL1
SCHEMBL23350453 0.67 NAMPT (0.38) L3MBTL3HTR2CL3MBTL1
SCHEMBL21671683 0.66 KDM4E (0.43) WEE1
SCHEMBL26032155 0.66 AKR1C3 (0.33)
SCHEMBL25925007 0.65 HTR2C (0.36) HTR2C
SCHEMBL25975795 0.64 POLB (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023109892-A1 COMPOUND FOR INHIBITING OR DEGRADING BRD9, AND COMPOSITION AND PHARMACEUTICAL USE THEREOF 海思科医药集团股份有限公司 2023-06-22 WO disclosed