Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 7/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.62 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.39 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2587497 | 0.81 | NCF1 (0.58) | NCF1ADRB2ACVR1CYP3A4TSHR | |
| SCHEMBL15673603 | 0.81 | NCF1 (0.53) | NCF1ADRB2CYP3A4TSHRNFKB1 | |
| SCHEMBL900231 | 0.77 | NCF1 (1.00) | NCF1ADRB2ACVR1TSHRNFKB1 | |
| SCHEMBL30041391 | 0.77 | NCF1 (1.00) | NCF1ADRB2ACVR1TSHRNFKB1 | |
| Hydrochloric Acid SCHEMBL30061214 | 0.76 | NCF1 (0.97) | NCF1ADRB2ACVR1TSHRNFKB1 | |
| SCHEMBL23412205 | 0.72 | NCF1 (0.88) | NCF1ADRB2TSHRNFKB1ADRB1 | |
| SCHEMBL30060463 | 0.69 | ALDH1A1 (0.65) | NCF1ADRB2MAPT | |
| SCHEMBL900373 | 0.69 | NCF1 (0.62) | NCF1ADRB2ACVR1CYP3A4TSHR | |
| SCHEMBL900393 | 0.68 | ADRB2 (0.50) | NCF1ADRB2ACVR1BMPR1BBMPR1A | |
| SCHEMBL30735573 | 0.68 | ADRB2 (0.50) | NCF1ADRB2ACVR1BMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9085557-B2 | Quinolylpiperazino substituted thiolactone compounds and process for the preparation thereof | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2015-07-21 | — | — | US | disclosed |
| EP-2566863-B1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2014-05-14 | — | — | EP | disclosed |
| US-20130190489-A1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2013-07-25 | — | — | US | disclosed |
| EP-2566863-A1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011138666-A1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2011-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130190489-A1 | QUINOLYLPIPERAZINO SUBSTITUTED THIOLACTONE COMPOUNDS AND PROCESS FOR THE PREPARATION THEREOF | SQOR, TST, FDPS | NCF1 3136/4885ADRB2 2221/4885ACVR1 4229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.