Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.56 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.56 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.56 |
| ▸ | ABAT | P80404 | 1/20 | 0.55 |
| ▸ | LOXL2 | Q9Y4K0 | 6/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | TPSAB1 | Q15661 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | F11 | P03951 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL31055587 | 0.88 | ABAT (0.60) | ABATLOXL2HRH3TPSAB1HDAC3 | |
| Glycine SCHEMBL15655272 | 0.85 | LOXL2 (0.56) | GLRA1SLC6A9OR51E2LOXL2SMN1; SMN2 | |
| SCHEMBL933080 | 0.84 | CA2 (0.62) | ABATLOXL2TPSAB1HDAC3HDAC6 | |
| Hydrochloric Acid SCHEMBL2575898 | 0.82 | CA2 (0.60) | ABATTPSAB1HDAC3HDAC6NCOR2 | |
| Hydrochloric Acid SCHEMBL11146854 | 0.82 | CA2 (0.60) | ABATTPSAB1HDAC3HDAC6NCOR2 | |
| SCHEMBL5033023 | 0.80 | FFAR1 (0.65) | CA1CA2 | |
| Aminomethylbenzoic Acid SCHEMBL9344424 | 0.79 | ALDH1A1 (0.60) | ABATLOXL2TPSAB1HDAC3HDAC6 | |
| Aminomethylbenzoic Acid SCHEMBL38758 | 0.79 | ALDH1A1 (0.60) | ABATLOXL2TPSAB1HDAC3HDAC6 | |
| Benzene SCHEMBL734439 | 0.78 | LOXL2 (0.80) | ABATLOXL2HRH3TAAR1F10 | |
| SCHEMBL15828 | 0.78 | HRH3 (0.79) | ABATLOXL2HRH3TAAR1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569378-A1 | PRINTING PROCESS, POLYMER AND INK | FUJIFILM Imaging Colorants Limited (GB) | 2013-03-20 | — | — | EP | disclosed |
| WO-2011141744-A1 | PRINTING PROCESS, POLYMER AND INK | FUJIFILM IMAGING COLORANTS LIMITED (GB) | 2011-11-17 | — | — | WO | disclosed |