SCHEMBL25968959

SCHEMBL25968959

Cc1cc(F)c(N2CCC(COc3ccc(Cl)c4[nH]c(=S)ccc34)CC2)c(F)c1

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 7/20 0.37
MGLL Q99685 6/20 0.35
EGFR P00533 2/20 0.33
FGFR1 P11362 1/20 0.33
FLT1 P17948 1/20 0.33
FLT4 P35916 1/20 0.33
KDR P35968 1/20 0.33
BRD4 O60885 1/20 0.33
DCPS Q96C86 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20612995 0.92 FFAR4 (0.36) FFAR4MGLLEGFRFGFR1FLT1
SCHEMBL25968868 0.77 FFAR4 (0.41) FFAR4MGLLDCPS
SCHEMBL20612937 0.72 FFAR4 (0.42) FFAR4EGFRFGFR1FLT1FLT4
SCHEMBL25968983 0.71 FFAR4 (0.43) FFAR4MGLL
SCHEMBL25969105 0.71 MGLL (0.44) FFAR4MGLL
SCHEMBL20613092 0.71 FFAR4 (0.46) FFAR4EGFRFGFR1FLT1FLT4
SCHEMBL25967008 0.70 EGFR (0.39) MGLLEGFRFGFR1FLT1FLT4
SCHEMBL20597349 0.70
SCHEMBL25966865 0.69 ADRB3 (0.46) FFAR4DCPS
SCHEMBL25970669 0.69 FFAR4 (0.39) FFAR4EGFRFGFR1FLT1FLT4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3421454-B9 PIPERIDINE DERIVATIVE OTSUKA PHARMA CO LTD (JP) 2023-08-09 EP disclosed