Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.45 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2596936 | 0.82 | FAAH (0.46) | GPR119FAAHSTS | |
| SCHEMBL2598399 | 0.77 | GPR119 (0.47) | GPR119IRAK4HCAR1POLB | |
| SCHEMBL31435997 | 0.77 | ALDH1A1 (0.45) | GPR119IRAK4DDB1CRBNSTS | |
| SCHEMBL29040774 | 0.76 | GPR119 (0.45) | GPR119IRAK4HCAR1DDB1CRBN | |
| SCHEMBL25198478 | 0.76 | HCAR1 (0.44) | GPR119HCAR1METDDB1CRBN | |
| SCHEMBL31435934 | 0.76 | IRAK4 (0.44) | GPR119IRAK4HCAR1METFAAH | |
| SCHEMBL25200960 | 0.76 | DDB1 (0.40) | GPR119IRAK4METDDB1CRBN | |
| SCHEMBL25219348 | 0.75 | DDB1 (0.40) | GPR119IRAK4HCAR1METDDB1 | |
| SCHEMBL1582522 | 0.75 | GPR119 (0.47) | GPR119IRAK4HCAR1DDB1CRBN | |
| SCHEMBL20135591 | 0.74 | GPR119 (0.50) | GPR119IRAK4HCAR1METDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146287-A1 | PYRAZOLO[4,3-B]PYRIDINE-7-AMINE INHIBITORS OF ALK5 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-11-24 | — | — | WO | disclosed |