Sugi Predict

Sugi Predict / Compounds / SCHEMBL2599586

SCHEMBL2599586

SCHEMBL2599586

C=Cc1c(C(=O)OC)nc(Cl)c(F)c1N

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ NPSR1 Q6W5P4 1/20 0.38
▸ ALDH1A1 P00352 7/20 0.37
▸ KDM4E B2RXH2 6/20 0.37
▸ L3MBTL1 Q9Y468 4/20 0.37
▸ SMN1; SMN2 Q16637 4/20 0.37
▸ PKM P14618 2/20 0.37
▸ MAPT P10636 2/20 0.35
▸ ATM Q13315 2/20 0.35
▸ LMNA P02545 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ F2 P00734 1/20 0.33
▸ RCE1 Q9Y256 1/20 0.33
▸ ABL1 P00519 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32
▸ NQO2 P16083 2/20 0.32
▸ HPGD P15428 2/20 0.31
▸ HSD17B10 Q99714 1/20 0.31
▸ KDM4C Q9H3R0 1/20 0.30
▸ RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2599666 0.85 L3MBTL1 (0.45) NPSR1ALDH1A1KDM4EL3MBTL1SMN1; SMN2
SCHEMBL11027966 0.84 NPSR1 (0.37) NPSR1ALDH1A1KDM4EL3MBTL1SMN1; SMN2
SCHEMBL11025354 0.84 NPSR1 (0.37) NPSR1ALDH1A1KDM4EL3MBTL1SMN1; SMN2
SCHEMBL11025351 0.84 NPSR1 (0.37) NPSR1ALDH1A1KDM4EL3MBTL1SMN1; SMN2
SCHEMBL11025358 0.84 NPSR1 (0.37) NPSR1ALDH1A1KDM4EL3MBTL1SMN1; SMN2
SCHEMBL11027963 0.84 NPSR1 (0.37) NPSR1ALDH1A1KDM4EL3MBTL1SMN1; SMN2
SCHEMBL11024150 0.82 KDM4E (0.35) NPSR1ALDH1A1KDM4EL3MBTL1SMN1; SMN2
SCHEMBL11024145 0.82 KDM4E (0.35) NPSR1ALDH1A1KDM4EL3MBTL1SMN1; SMN2
SCHEMBL11026970 0.82 TDP1 (0.46) TDP1
SCHEMBL1917106 0.82 KDM4E (0.49) ALDH1A1KDM4EL3MBTL1SMN1; SMN2PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 98 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2970185-B1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-07-12 — — EP disclosed
EP-2970185-B1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-07-12 — — EP disclosed
EP-3440938-B1 4-AMINO-6-(4-SUBSTITUTED-PHENYL)-PICOLINATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-07-12 — — EP disclosed
EP-3569600-B1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-06-14 — — EP disclosed
EP-3569600-B1 4-AMINO-6-(HETEROCYCLIC)PICOLINATES AND 6-AMINO-2-(HETEROCYCLIC)PYRIMIDINE-4-CARBOXYLATES AND THEIR USE AS HERBICIDES CORTEVA AGRISCIENCE LLC (US) 2023-06-14 — — EP disclosed
CN-108689924-B 4-amino-6- (4-substituted phenyl) -pyridine-2-carboxylic acid esters and their use as herbicides 美国陶氏益农公司 2022-04-12 — — CN disclosed
CN-113292502-A Novel 4-aminopyridine and 6-aminopyrimidine carboxylates as herbicides 美国陶氏益农公司 2021-08-24 — — CN disclosed
CN-111704602-A Heterocyclylpyridines and their use as herbicides 美国陶氏益农公司 2020-09-25 — — CN disclosed
US-10765114-B2 4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinates and 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their use as herbicides DOW AGROSCIENCES LLC (US) 2020-09-08 — — US disclosed
US-10765114-B2 4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinates and 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their use as herbicides DOW AGROSCIENCES LLC (US) 2020-09-08 — — US disclosed
US-8835409-B2 3-alkenyl-6-halo-4-aminopicolinates and their use as herbicides DOW AGROSCIENCES, LLC. (US) 2014-09-16 — — US disclosed
EP-2571852-A1 CHEMICAL COMPOUNDS Syngenta Limited (GB) 2013-03-27 — — EP disclosed
US-20130065757-A1 CHEMICAL COMPOUNDS SYNGENTA LIMITED (GB) 2013-03-14 — — US disclosed
US-20130065757-A1 CHEMICAL COMPOUNDS SYNGENTA LIMITED (GB) 2013-03-14 — — US disclosed
US-20130065757-A1 CHEMICAL COMPOUNDS SYNGENTA LIMITED (GB) 2013-03-14 — — US disclosed
US-20120190548-A1 3-ALKENYL-6-HALO-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2012-07-26 — — US disclosed
US-20120190548-A1 3-ALKENYL-6-HALO-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2012-07-26 — — US disclosed
US-20120190548-A1 3-ALKENYL-6-HALO-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2012-07-26 — — US disclosed
WO-2011144891-A1 CHEMICAL COMPOUNDS SYNGENTA LIMITED (GB) 2011-11-24 — — WO disclosed
WO-2011144891-A1 CHEMICAL COMPOUNDS SYNGENTA LIMITED (GB) 2011-11-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10765114-B2 4-amino-6-(pyridyl and 2-substitutedphenyl)-picolinates and 6-amino-2-(pyridyl and 2-substitutedphenyl)-pyrimidine-4-carboxylates and their use as herbicides DDT, P2RX6, PLPBP NPSR1 1728/4885ALDH1A1 951/4885KDM4E 1211/4885
US-20130065757-A1 CHEMICAL COMPOUNDS HPD, PPOX, PIN1 NPSR1 287/4885ALDH1A1 1856/4885KDM4E 4447/4885
US-20120190548-A1 3-ALKENYL-6-HALO-4-AMINOPICOLINATES AND THEIR USE AS HERBICIDES ATL3, AAAS, HDHD5 NPSR1 2555/4885ALDH1A1 1051/4885KDM4E 1379/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.