Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 known ✓ | Q9H4B7 | 2/20 | 0.45 |
| ▸ | WDR5 | P61964 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | MYC | P01106 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30152196 | 0.89 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1AOX1MAPTHSD17B10 | |
| SCHEMBL41497 | 0.89 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1AOX1MAPTHSD17B10 | |
| Formaldehyde SCHEMBL27568605 | 0.87 | ALDH1A1 (0.52) | WDR5SMN1; SMN2MYCALDH1A1AOX1 | |
| Bicarbonate SCHEMBL28501235 | 0.85 | GAA (0.54) | SMN1; SMN2ALDH1A1AOX1MAPTHSD17B10 | |
| SCHEMBL19509694 | 0.78 | ALDH1A1 (0.45) | WDR5SMN1; SMN2GLAMYCALDH1A1 | |
| SCHEMBL27584635 | 0.76 | SMN1; SMN2 (0.59) | WDR5SMN1; SMN2GLAMYCALDH1A1 | |
| SCHEMBL2123784 | 0.76 | PTGS1 (0.57) | SMN1; SMN2ALDH1A1AOX1MAPTHSD17B10 | |
| Hydrochloric Acid SCHEMBL27582675 | 0.75 | SMN1; SMN2 (0.58) | WDR5SMN1; SMN2GLAMYCALDH1A1 | |
| Sulfuric Acid SCHEMBL28214565 | 0.75 | CA1 (0.53) | SMN1; SMN2GLAALDH1A1MAPTTSHR | |
| SCHEMBL1790129 | 0.74 | SMN1; SMN2 (0.65) | WDR5SMN1; SMN2GLAMYCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2574192-B1 | PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF | RHODIA CHINA CO LTD (CN) | 2016-09-21 | — | — | EP | disclosed |
| US-8975431-B2 | Process for preparing an ortho-substituted 5-halophenol and a synthesis intermediate thereof | RHODIA OPERATIONS (FR) | 2015-03-10 | — | — | US | disclosed |
| EP-2574192-A1 | PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF | Rhodia (China) Co., Ltd. (CN) | 2013-04-03 | — | — | EP | disclosed |
| US-20130066097-A1 | PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF | RHODIA (CHINA) CO., LTD. (CN) | 2013-03-14 | — | — | US | disclosed |
| WO-2011143819-A1 | PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF | RHODIA (CHINA) CO., LTD. (CN) | 2011-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130066097-A1 | PROCESS FOR PREPARING AN ORTHO-SUBSTITUTED 5-HALOPHENOL AND A SYNTHESIS INTERMEDIATE THEREOF | HDHD5, HPD, NISCH | TUBB1 4726/4885WDR5 3551/4885SMN1; SMN2 4595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.