Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Pramoxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.94 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.94 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.94 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.94 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.94 |
| ▸ | HTR2A | P28223 | 1/20 | 0.94 |
| ▸ | SCN1A | P35498 | 1/20 | 0.94 |
| ▸ | HTR2B | P41595 | 1/20 | 0.94 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.94 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.94 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.94 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.94 |
| ▸ | LMNA | P02545 | 3/20 | 0.91 |
| ▸ | USP2 | O75604 | 2/20 | 0.91 |
| ▸ | THRB | P10828 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pramoxine SCHEMBL26020 | 0.97 | ALDH1A1 (1.00) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| Pramoxine SCHEMBL180542 | 0.95 | LMNA (1.00) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL23804878 | 0.92 | HRH3 (0.91) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL29508217 | 0.90 | ALDH1A1 (0.88) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| Pramoxine SCHEMBL29048599 | 0.88 | ALDH1A1 (0.83) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL29508145 | 0.88 | ALDH1A1 (0.82) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL29508184 | 0.87 | ALDH1A1 (0.81) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL13186317 | 0.86 | HRH3 (0.80) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL171264 | 0.86 | HRH3 (0.79) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL23804879 | 0.86 | HRH3 (0.79) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1366874-A | Personal nursing compound | JOHNSON & JOHNSON CONSUMER (US) | 2002-09-04 | — | — | CN | claimed |
| US-4877781-A | TIXOCORTOL PIVALATE, EPHEDRINE SULFATE, PRAMOXINE HYDROCHLORIDE; ANTIINFLAMMATORY AGENTS FOR HEMORRHOIDS | LaHaye, Peter G. (US) | 1989-10-31 | — | — | US | claimed |
| US-12508218-B2 | Coating compositions | COTY INC. (US) | 2025-12-30 | — | — | US | disclosed |
| US-20250152487-A1 | FRAGRANCE COMPOSITIONS AND USES THEREOF | COTY INC. | 2025-05-15 | — | — | US | disclosed |
| US-20250127707-A1 | FRAGRANCE FORMULATION | COTY INC. | 2025-04-24 | — | — | US | disclosed |
| US-20250127694-A1 | FRAGRANCE COMPOSITIONS AND USES THEREOF | COTY INC. | 2025-04-24 | — | — | US | disclosed |
| US-20250032371-A1 | ETHANOL-FREE FRAGRANCE CHASSIS | COTY INC. | 2025-01-30 | — | — | US | disclosed |
| US-12178896-B2 | Fragrance compositions and uses thereof | COTY INC. (US) | 2024-12-31 | — | — | US | disclosed |
| US-20230285261-A1 | FRAGRANCE COMPOSITION COMPRISING A FRAGRANCE COMPONET AND A NON-ODOROUS FRAGRANCE MODULATOR | JPMORGAN CHASE BANK, N.A. | 2023-09-14 | — | — | US | disclosed |
| CN-116466000-A | Method for rapidly determining 176 PPCPs content in source water | 福建省产品质量检验研究院(福建省缺陷产品召回技术中心) | 2023-07-21 | — | — | CN | disclosed |
| EP-3141239-B1 | FRAGRANCE COMPOSITIONS AND USES THEREOF | PROCTER & GAMBLE (US) | 2023-05-10 | — | — | EP | disclosed |
| US-20160362630-A1 | Fragrance Compositions and Uses Thereof | THE PROCTER & GAMBLE COMPANY | 2016-12-15 | — | — | US | disclosed |
| US-20160362631-A1 | Fragrance Fixatives and Compositions Comprising Thereof | THE PROCTER & GAMBLE COMPANY | 2016-12-15 | — | — | US | disclosed |
| EP-2846788-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | Akron Molecules AG (AT) | 2015-03-18 | — | — | EP | disclosed |
| CN-104059029-A | Preparation method of pramoxine hydrochloride | STONECREEK LIFE TECHNOLOGIES INC | 2014-09-24 | — | — | CN | disclosed |
| WO-2013167743-A1 | USE OF COMPOUNDS FOR THE TREATMENT OF PAIN | AKRON MOLECULES GMBH (AT) | 2013-11-14 | — | — | WO | disclosed |
| WO-2009148684-A1 | BOTANICAL COMPOSITION AND ITS USES | MICRO-DOSE LIFE SCIENCES, LLC (US) | 2009-12-10 | — | — | WO | disclosed |
| US-20090297643-A1 | BOTANICAL COMPOSITION AND ITS USES | MICRO-DOSE LIFE SCIENCES, LLC (US) | 2009-12-03 | — | — | US | disclosed |
| US-4877781-A | TIXOCORTOL PIVALATE, EPHEDRINE SULFATE, PRAMOXINE HYDROCHLORIDE; ANTIINFLAMMATORY AGENTS FOR HEMORRHOIDS | LaHaye, Peter G. (US) | 1989-10-31 | — | — | US | disclosed |
| US-4877781-A | TIXOCORTOL PIVALATE, EPHEDRINE SULFATE, PRAMOXINE HYDROCHLORIDE; ANTIINFLAMMATORY AGENTS FOR HEMORRHOIDS | LaHaye, Peter G. (US) | 1989-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12178896-B2 | Fragrance compositions and uses thereof | FHIT, ALG3, FEM1B | CHRM2 3417/4885CHRM1 3097/4885ALDH1A1 275/4885 |
| US-20250032371-A1 | ETHANOL-FREE FRAGRANCE CHASSIS | OR51E2, FDFT1, ELANE | CHRM2 511/4885CHRM1 483/4885ALDH1A1 694/4885 |
| US-20250127694-A1 | FRAGRANCE COMPOSITIONS AND USES THEREOF | TRPA1, TRPV1, NAA40 | CHRM2 3657/4885CHRM1 2639/4885ALDH1A1 1624/4885 |
| US-20250127707-A1 | FRAGRANCE FORMULATION | PUF60, POLM, ADH5 | CHRM2 3059/4885CHRM1 1949/4885ALDH1A1 257/4885 |
| US-20230285261-A1 | FRAGRANCE COMPOSITION COMPRISING A FRAGRANCE COMPONET AND A NON-ODOROUS FRAGRANCE MODULATOR | OR51E2, TRPA1, FAM120A | CHRM2 1294/4885CHRM1 1014/4885ALDH1A1 1958/4885 |
| US-20160362630-A1 | Fragrance Compositions and Uses Thereof | CUTA, DPM1, PLIN5 | CHRM2 4240/4885CHRM1 4108/4885ALDH1A1 1263/4885 |
| US-12508218-B2 | Coating compositions | TAS2R40, TAS2R20, TAS2R10 | CHRM2 1456/4885CHRM1 1665/4885ALDH1A1 3806/4885 |
| US-20250152487-A1 | FRAGRANCE COMPOSITIONS AND USES THEREOF | FHIT, ALG3, FEM1B | CHRM2 3417/4885CHRM1 3097/4885ALDH1A1 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.