Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Pramoxine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.83 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.83 |
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.83 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.83 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.83 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.83 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.83 |
| ▸ | HTR2A | P28223 | 1/20 | 0.83 |
| ▸ | HTR2B | P41595 | 1/20 | 0.83 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.83 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.83 |
| ▸ | LMNA | P02545 | 3/20 | 0.81 |
| ▸ | USP2 | O75604 | 2/20 | 0.81 |
| ▸ | THRB | P10828 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | THRA | P10827 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pramoxine SCHEMBL26020 | 0.91 | ALDH1A1 (1.00) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| Pramoxine SCHEMBL180542 | 0.90 | LMNA (1.00) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| Pramoxine SCHEMBL4435138 | 0.88 | ALDH1A1 (0.94) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL23804878 | 0.87 | HRH3 (0.91) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL29508217 | 0.85 | ALDH1A1 (0.88) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL29508033 | 0.83 | THRB (0.84) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL29508145 | 0.82 | ALDH1A1 (0.82) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL29508184 | 0.82 | ALDH1A1 (0.81) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| Pramoxine SCHEMBL2505808 | 0.82 | ALDH1A1 (0.75) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 | |
| SCHEMBL23649331 | 0.81 | KMT2A (0.67) | ALDH1A1HRH3MAPK1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109843921-B | Programmed death 1 ligand 1 (PD-L1) binding proteins and methods of use thereof | 艾欧凡斯生物治疗公司 | 2023-05-26 | — | — | CN | disclosed |