Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5942944 | 0.94 | HAO1 (0.54) | HAO1THRBKDM4EMEN1KMT2A | |
| SCHEMBL16023895 | 0.90 | HAO1 (0.42) | HAO1THRBKDM4EMEN1KMT2A | |
| SCHEMBL16838785 | 0.81 | HAO1 (0.49) | HAO1KDM4EMEN1KMT2ASCN9A | |
| SCHEMBL16838788 | 0.77 | NPBWR1 (0.45) | HAO1KDM4EMEN1KMT2AEGLN1 | |
| SCHEMBL16761723 | 0.77 | ALDH1A1 (0.64) | HAO1KDM4ESCN9ASCN5AKCNH2 | |
| SCHEMBL5942714 | 0.76 | LTA4H (0.46) | HAO1THRBKDM4EMEN1KMT2A | |
| SCHEMBL3584036 | 0.76 | L3MBTL1 (0.47) | HAO1THRBKDM4EMEN1KMT2A | |
| SCHEMBL8332212 | 0.76 | KDM4E (0.58) | THRBKDM4EMEN1KMT2APOLB | |
| SCHEMBL16838789 | 0.76 | RAB9A (0.47) | HAO1THRBKDM4EMEN1KMT2A | |
| SCHEMBL8688799 | 0.76 | THRB (0.44) | THRBKDM4EMEN1KMT2AMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023122778-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS | GOSSAMER BIO SERVICES, INC. (US) | 2023-06-29 | — | — | WO | disclosed |