Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | CRHR1 | P34998 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26021777 | 0.88 | CRHR1 (0.44) | NR1I2ADORA3OPRM1OPRK1CRHR1 | |
| SCHEMBL26621469 | 0.82 | ATAD2 (0.49) | NR1I2ADORA3OPRM1OPRK1CRHR1 | |
| SCHEMBL2951133 | 0.80 | HDAC1 (0.45) | CRHR1HDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL11526516 | 0.80 | BRD4 (0.55) | CRHR1HDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL26024965 | 0.78 | NR1I2 (0.36) | NR1I2ADORA3OPRM1OPRK1HDAC1 | |
| SCHEMBL7234150 | 0.78 | HTR7 (0.49) | DRD2POLBDRD4NOTUMDRD5 | |
| SCHEMBL7236659 | 0.77 | MAPT (0.43) | NR1I2ADORA3OPRM1OPRK1MAPT | |
| SCHEMBL27827013 | 0.77 | HDAC1 (0.40) | CRHR1HDAC1HDAC8HDAC6KMT2A | |
| SCHEMBL26021803 | 0.77 | BMPR1B (0.48) | OPRK1CRHR1HDAC1HDAC8HDAC6 | |
| SCHEMBL25899906 | 0.77 | BMPR1B (0.47) | CRHR1HDAC1HDAC8HDAC6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | HERCULES CAPITAL, INC., AS AGENT | 2023-08-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230265096-A1 | APOL1 INHIBITORS AND METHODS OF USE | APOL1, APOB, LDLR | NR1I2 186/4885ADORA3 2389/4885OPRM1 683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.