Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 4/20 | 0.51 |
| ▸ | HTR1B | P28222 | 6/20 | 0.47 |
| ▸ | HTR1D | P28221 | 5/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26078550 | 0.87 | ADRA2C (0.43) | NISCHHTR1BHTR1DADRA2CADRA2A | |
| SCHEMBL26078454 | 0.85 | HTR1B (0.49) | NISCHHTR1BHTR1DADRA2CADRA2A | |
| SCHEMBL26078505 | 0.80 | TAAR1 (0.56) | NISCHHTR1BHTR1DADRA2CADRA2A | |
| SCHEMBL26078506 | 0.80 | ADRA2A (0.46) | NISCHHTR1BHTR1DADRA2CADRA2A | |
| SCHEMBL26078509 | 0.79 | HTR1D (0.49) | NISCHHTR1BHTR1DADRA2CADRA2A | |
| SCHEMBL26078452 | 0.78 | HTR1D (0.68) | NISCHHTR1BHTR1DADRA2CADRA2A | |
| SCHEMBL26078605 | 0.78 | HTR1D (0.48) | NISCHHTR1BHTR1DADRA2CADRA2A | |
| SCHEMBL26078608 | 0.78 | HTR1D (0.48) | NISCHHTR1BHTR1DADRA2CADRA2A | |
| SCHEMBL26078611 | 0.78 | HTR1D (0.48) | NISCHHTR1BHTR1DADRA2CADRA2A | |
| SCHEMBL26078482 | 0.77 | TAAR1 (0.56) | NISCHHTR1BHTR1DADRA2CADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230312524-A1 | ALPHA1A-ADRENERGIC RECEPTOR AGONISTS AND METHODS OF USE | CURASEN THERAPEUTICS, INC. | 2023-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230312524-A1 | ALPHA1A-ADRENERGIC RECEPTOR AGONISTS AND METHODS OF USE | ADRA1A, ADRB1, ADRA1D | NISCH 1881/4885HTR1B 105/4885HTR1D 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.