Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CHKA | P35790 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CCR1 | P32246 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | IDE | P14735 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.46 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT5B | Q4FZB7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11891560 | 0.86 | NR4A2 (0.56) | NR4A2SOS2CYP1A2CHKAKMT2A | |
| SCHEMBL18710418 | 0.85 | NR4A2 (0.51) | NR4A2SOS2CYP1A2CHKAKMT2A | |
| SCHEMBL669631 | 0.82 | NR4A2 (0.56) | NR4A2SOS2CYP1A2CHKAKMT2A | |
| SCHEMBL27484900 | 0.81 | NR4A2 (0.51) | NR4A2SOS2CYP1A2CHKAKMT2A | |
| SCHEMBL10315757 | 0.80 | HTR1A (0.51) | CYP1A2KMT2AMAPTCCR1MEN1 | |
| SCHEMBL4548621 | 0.80 | FGFR2 (0.42) | TDP1ALOX15HSD17B10 | |
| Hydrochloric Acid SCHEMBL27485590 | 0.80 | NR4A2 (0.50) | NR4A2SOS2CYP1A2CHKAKMT2A | |
| SCHEMBL14549628 | 0.79 | FERMT2 (0.45) | FERMT2 | |
| SCHEMBL9541492 | 0.78 | NR4A2 (0.51) | NR4A2SOS2CYP1A2CHKAKMT2A | |
| SCHEMBL669359 | 0.77 | NR4A2 (0.50) | NR4A2SOS2CYP1A2CHKAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030853-B2 | MASP-2 inhibitors and methods of use | OMEROS CORPORATION (US) | 2024-07-09 | — | — | US | disclosed |
| US-12030853-B2 | MASP-2 inhibitors and methods of use | OMEROS CORPORATION (US) | 2024-07-09 | — | — | US | disclosed |
| US-20210171461-A1 | MASP-2 INHIBITORS AND METHODS OF USE | OMEROS CORPORATION | 2021-06-10 | — | — | US | disclosed |
| US-10889611-B2 | Sialyltransferase inhibitors and uses thereof | ACADEMIA SINICA (TW) | 2021-01-12 | — | — | US | disclosed |
| US-10450299-B2 | Substituted quinazoline derivatives as DNA methyltransferase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2019-10-22 | — | — | US | disclosed |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-05-03 | — | — | US | disclosed |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2018-05-03 | — | — | US | disclosed |
| US-9951044-B2 | Quinazoline derivatives and their use as DNA methyltransferase inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2018-04-24 | — | — | US | disclosed |
| US-9951044-B2 | Quinazoline derivatives and their use as DNA methyltransferase inhibitors | PIERRE FABRE MEDICAMENT (FR) | 2018-04-24 | — | — | US | disclosed |
| US-9938236-B2 | Antiviral agents against HBV infection | DREXEL UNIVERSITY (US) | 2018-04-10 | — | — | US | disclosed |
| US-7745444-B2 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-29 | — | — | US | disclosed |
| US-20100124545-A1 | CYCLIC CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF AS OF HEPATITIS C VIRUS | ACHILLION PHARMACEUTICALS, INC. (US) | 2010-05-20 | — | — | US | disclosed |
| US-7574340-B2 | Small molecules and a pharmacophore model for inhibition of botulinum toxin and methods of making and using thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 2009-08-11 | — | — | US | disclosed |
| US-20090082261-A1 | UREA-CONTAINING PEPTIDES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS, INC. (US) | 2009-03-26 | — | — | US | disclosed |
| US-20090048297-A1 | 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION | ACHILLION PHARMACEUTICALS (US) | 2009-02-19 | — | — | US | disclosed |
| US-20080311079-A1 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-12-18 | — | — | US | disclosed |
| US-20080300240-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORPORATION (US) | 2008-12-04 | — | — | US | disclosed |
| US-7432379-B2 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7378422-B2 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300240-A1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | PDE10A, PDE9A, PDE7A | NR4A2 1752/4885SOS2 4420/4885CYP1A2 1182/4885 |
| US-10889611-B2 | Sialyltransferase inhibitors and uses thereof | ST6GAL1, NEU1, GALNT1 | NR4A2 2600/4885SOS2 2424/4885CYP1A2 3815/4885 |
| US-10450299-B2 | Substituted quinazoline derivatives as DNA methyltransferase inhibitors | DNMT1, DNMT3A, DNMT3B | NR4A2 1884/4885SOS2 2726/4885CYP1A2 284/4885 |
| US-20090082261-A1 | UREA-CONTAINING PEPTIDES AS INHIBITORS OF VIRAL REPLICATION | VIP, SLC14A1, RPL35 | NR4A2 4130/4885SOS2 4584/4885CYP1A2 4772/4885 |
| US-20090048297-A1 | 4-AMINO-4-OXOBUTANOYL PEPTIDES AS INHIBITORS OF VIRAL REPLICATION | VIP, ZC3HAV1, CCL5 | NR4A2 2376/4885SOS2 4681/4885CYP1A2 4528/4885 |
| US-20080311079-A1 | Inhibitors of serine proteases, particularly HCV NS3-NS4A protease | SERPINB1, PRSS1, SPINT2 | NR4A2 3687/4885SOS2 1274/4885CYP1A2 851/4885 |
| US-20100124545-A1 | CYCLIC CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF AS OF HEPATITIS C VIRUS | CPS1, CCKAR, C1R | NR4A2 1447/4885SOS2 4635/4885CYP1A2 1423/4885 |
| US-20180118717-A1 | Substituted Quinazoline Derivatives as DNA Methyltransferase Inhibitors | DNMT1, DNMT3A, DNMT3B | NR4A2 1884/4885SOS2 2726/4885CYP1A2 284/4885 |
| US-12030853-B2 | MASP-2 inhibitors and methods of use | MASP2, METAP2, SPINT2 | NR4A2 4047/4885SOS2 1413/4885CYP1A2 4271/4885 |
| US-20210171461-A1 | MASP-2 INHIBITORS AND METHODS OF USE | MASP2, METAP2, SPINT2 | NR4A2 4047/4885SOS2 1413/4885CYP1A2 4271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.