SCHEMBL2612434

SCHEMBL2612434

COc1c(C)cc(C2C(=O)Oc3c2cc(C(C)(C)C)cc3C(C)(C)C)cc1C

nearest known ligand 0.36

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GABBR2 O75899 1/20 0.36
GABBR1 Q9UBS5 1/20 0.36
MAPT P10636 1/20 0.35
ALDH1A1 P00352 1/20 0.32
HPGD P15428 1/20 0.32
AKR1B1 P15121 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22068544 0.95 GABBR2 (0.35) GABBR2GABBR1MAPTALDH1A1HPGD
SCHEMBL21610912 0.89 GABBR2 (0.36) GABBR2GABBR1
SCHEMBL23071656 0.88 GABBR2 (0.35) GABBR2GABBR1
SCHEMBL17021489 0.88 GABBR2 (0.35) GABBR2GABBR1MAPT
SCHEMBL5083915 0.87 GABBR2 (0.39) GABBR2GABBR1ALDH1A1
SCHEMBL13599675 0.87 GABBR2 (0.34) GABBR2GABBR1ALDH1A1
SCHEMBL18516993 0.87 GABBR2 (0.34) GABBR2GABBR1
SCHEMBL39328 0.86 GABBR2 (0.39) GABBR2GABBR1
SCHEMBL29466124 0.86 GABBR2 (0.34) GABBR2GABBR1
SCHEMBL39102 0.86 GABBR2 (0.36) GABBR2GABBR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11767338-B2 3-phenyl-benzofuran-2-one diphosphate derivatives as stabilizers BASF SE (DE) 2023-09-26 US disclosed
US-20220145053-A1 Stabilized Polyolefin Compositions Comprising Benzofuranones and Hindered Phenolic Antioxidants BASF SE (DE) 2022-05-12 US disclosed
US-20210253617-A1 3-PHENYL-BENZOFURAN-2-ONE DIPHOSPHATE DERIVATIVES AS STABILIZERS BASF SCHWEIZ AG (CH) 2021-08-19 US disclosed
US-10941285-B2 Stabilized polyolefin compositions comprising benzofuranones and acid scavengers BASF SE (DE) 2021-03-09 US disclosed
US-10941286-B2 Stabilized polyolefin compositions comprising benzofuranones and hindered amine light stabilizers BASF SE (DE) 2021-03-09 US disclosed
US-10934423-B2 Stabilized polyolefin compositions comprising benzofuranones and organophosphorus stabilizers BASF SE (DE) 2021-03-02 US disclosed
US-10913841-B2 Stabilized polyolefin compositions comprising benzofuranones and hindered phenolic antioxidants BASF SE (DE) 2021-02-09 US disclosed
US-20200216638-A1 Stabilized Polyolefin Compositions Comprising Benzofuranones and Hindered Amine Light Stabilizers BASF SCHWEIZ AG (CH) 2020-07-09 US disclosed
US-20200181364-A1 Stabilized Polyolefin Compositions Comprising Benzofuranones and Acid Scavengers BASF SCHWEIZ AG (CH) 2020-06-11 US disclosed
EP-2464739-B1 METHODS IN CELL CULTURES, AND RELATED INVENTIONS, EMPLOYING CERTAIN ADDITIVES BASF SE (DE) 2016-01-13 EP disclosed
US-20100069535-A1 Cellulose Ester Optical Film, Polarizing Plate and Liquid Crystal Display Using the Same, Method of Manufacturing Cellulose Ester Optical Film, and Copolymer. KONICA MINOLTA OPTO, INC. (JP) 2010-03-18 US disclosed
US-20100069535-A1 Cellulose Ester Optical Film, Polarizing Plate and Liquid Crystal Display Using the Same, Method of Manufacturing Cellulose Ester Optical Film, and Copolymer. KONICA MINOLTA OPTO, INC. (JP) 2010-03-18 US disclosed
US-20090246416-A1 OPTICAL FILM, METHOD OF MANUFACTURING THE SAME, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE KONICA MINOLTA OPTO, INC. (JP) 2009-10-01 US disclosed
US-20090246416-A1 OPTICAL FILM, METHOD OF MANUFACTURING THE SAME, POLARIZING PLATE, AND LIQUID CRYSTAL DISPLAY DEVICE KONICA MINOLTA OPTO, INC. (JP) 2009-10-01 US disclosed
US-20080122128-A1 Method for producing optical film KONICA MINOLTA OPTO, INC. (JP) 2008-05-29 US disclosed
US-20080122128-A1 Method for producing optical film KONICA MINOLTA OPTO, INC. (JP) 2008-05-29 US disclosed
US-20070254115-A1 Polarizer protective film, manufacturing method thereof, polarizing plate and liquid crystal display KONICA MINOLTA OPTO, INC. (JP) 2007-11-01 US disclosed
US-20070254115-A1 Polarizer protective film, manufacturing method thereof, polarizing plate and liquid crystal display KONICA MINOLTA OPTO, INC. (JP) 2007-11-01 US disclosed
US-20070227652-A1 FILM FOR DISPLAY, POLARIZING PLATE AND MANUFACTURING METHOD THEREOF, AND LIQUID CRYSTAL DISPLAY KONICA MINOLTA OPTO, INC. (JP) 2007-10-04 US disclosed
US-20070227652-A1 FILM FOR DISPLAY, POLARIZING PLATE AND MANUFACTURING METHOD THEREOF, AND LIQUID CRYSTAL DISPLAY KONICA MINOLTA OPTO, INC. (JP) 2007-10-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10941286-B2 Stabilized polyolefin compositions comprising benzofuranones and hindered amine light stabilizers PUF60, PARG, PARN GABBR2 891/4885GABBR1 750/4885MAPT 140/4885
US-10941285-B2 Stabilized polyolefin compositions comprising benzofuranones and acid scavengers PUF60, PCBP1, MORF4L1 GABBR2 1285/4885GABBR1 1099/4885MAPT 1584/4885
US-10913841-B2 Stabilized polyolefin compositions comprising benzofuranones and hindered phenolic antioxidants PUF60, GPX4, BPTF GABBR2 3048/4885GABBR1 2779/4885MAPT 861/4885
US-20210253617-A1 3-PHENYL-BENZOFURAN-2-ONE DIPHOSPHATE DERIVATIVES AS STABILIZERS DHPS, PIR, NQO1 GABBR2 2199/4885GABBR1 2239/4885MAPT 1179/4885
US-10934423-B2 Stabilized polyolefin compositions comprising benzofuranones and organophosphorus stabilizers PUF60, MORF4L1, BRPF1 GABBR2 351/4885GABBR1 256/4885MAPT 1239/4885
US-11767338-B2 3-phenyl-benzofuran-2-one diphosphate derivatives as stabilizers DHPS, PIR, NQO1 GABBR2 2199/4885GABBR1 2239/4885MAPT 1179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.