SCHEMBL2614974

SCHEMBL2614974

Cc1cccc(-c2ccccc2Cl)n1

nearest known ligand 0.58

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 1/20 0.58
CCR8 P51685 1/20 0.58
GRM5 P41594 1/20 0.46
METAP2 P50579 1/20 0.46
HSD11B1 P28845 3/20 0.46
HSP90AA1 P07900 1/20 0.44
HSP90AB1 P08238 1/20 0.44
TGFBR1 P36897 7/20 0.44
IDO1 P14902 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
CNR2 P34972 1/20 0.43
MGAM O43451 1/20 0.42
GAA P10253 1/20 0.42
SI P14410 1/20 0.42
MGAM2 Q2M2H8 1/20 0.42
POLB P06746 1/20 0.42
KMT2A Q03164 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10539809 0.87 GRM5 (0.52) CCR1CCR8GRM5TGFBR1MGAM
SCHEMBL10537438 0.85 TGFBR1 (0.46) CCR1CCR8GRM5METAP2HSP90AA1
SCHEMBL10540409 0.84 HSP90AA1 (0.54) CCR1CCR8GRM5METAP2HSD11B1
SCHEMBL10537516 0.81 CCR1 (0.42) CCR1CCR8GRM5HSP90AA1HSP90AB1
SCHEMBL9369946 0.80 GRM5 (0.46) GRM5HSD11B1L3MBTL1CNR2MGAM
SCHEMBL12270088 0.80 CCR1 (0.58) CCR1CCR8METAP2TGFBR1KMT2A
SCHEMBL16166905 0.79 HSP90AA1 (0.44) HSD11B1HSP90AA1HSP90AB1IDO1L3MBTL1
SCHEMBL2615267 0.79 HSP90AA1 (0.57) CCR1CCR8HSD11B1HSP90AA1HSP90AB1
SCHEMBL38666057 0.79 HSP90AA1 (0.52) GRM5HSD11B1HSP90AA1HSP90AB1IDO1
SCHEMBL10374376 0.79 CCR1 (0.62) CCR1CCR8METAP2TGFBR1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230022157-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT FACTOR D MEDICAL DISORDERS ACHILLION PHARMACEUTICALS, INC. (US) 2023-01-26 US disclosed
EP-3110418-B1 ARYL, HETEROARYL, AND HETEROCYCLIC COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS ACHILLION PHARMACEUTICALS INC (US) 2019-11-06 EP disclosed
US-10301336-B2 Phosphonate compounds for treatment of complement mediated disorders ACHILLION PHARMACEUTICALS, INC. (US) 2019-05-28 US disclosed
US-9828396-B2 Alkyne compounds for treatment of complement mediated disorders ACHILLION PHARMACEUTICALS, INC. (US) 2017-11-28 US disclosed
US-9796741-B2 Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders ACHILLION PHARMACEUTICALS, INC. (US) 2017-10-24 US disclosed
US-20170298084-A1 AMIDE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS ACHILLION PHARMACEUTICALS, INC. (US) 2017-10-19 US disclosed
US-20170298085-A1 CARBAMATE, ESTER, AND KETONE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS ACHILLION PHARMACEUTICALS, INC. (US) 2017-10-19 US disclosed
US-20170260219-A1 PHOSPHONATE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS ACHILLION PHARMACEUTICALS, INC. (US) 2017-09-14 US disclosed
US-9758537-B2 Compounds for treatment of complement mediated disorders ACHILLION PHARMACEUTICALS (US) 2017-09-12 US disclosed
US-9732103-B2 Carbamate, ester, and ketone compounds for treatment of complement mediated disorders ACHILLION PHARMACEUTICALS, INC. (US) 2017-08-15 US disclosed
US-8785445-B2 7-phenoxychroman carboxylic acid derivatives ARRAY BIOPHARMA INC. (US) 2014-07-22 US disclosed
EP-2344486-B1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THEIR USE AS FAAH INHIBITORS SANOFI SA (FR) 2013-03-27 EP disclosed
US-20120101103-A1 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES ARRAY BIOPHARMA INC. (US) 2012-04-26 US disclosed
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-09-01 US disclosed
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-09-01 US disclosed
EP-0244130-B1 PROCESS FOR MAKING 6-ARYL-2-METHYL PYRIDINES ROHM AND HAAS COMPANY (US) 1990-01-17 EP disclosed
US-4804761-A Process for making 6-aryl-2-methylpyridines ROHM AND HAAS COMPANY (US) 1989-02-14 US disclosed
EP-0244130-A2 Process for making 6-aryl-2-methyl pyridines ROHM AND HAAS COMPANY (US) 1987-11-04 EP disclosed
EP-0243101-A2 Insecticidal 6-aryl-pyridine thiosemicarbazones ROHM AND HAAS COMPANY (US) 1987-10-28 EP disclosed
US-4696938-A Insecticidal 6-aryl-pyridine thiosemicarbazones ROHM AND HAAS COMPANY (US) 1987-09-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF MET, ALK, REL CCR1 297/4885CCR8 614/4885GRM5 954/4885
US-20170298084-A1 AMIDE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS CFD, TFPI, C9 CCR1 1386/4885CCR8 1820/4885GRM5 3157/4885
US-10301336-B2 Phosphonate compounds for treatment of complement mediated disorders CFD, TFPI, C1QBP CCR1 1999/4885CCR8 3451/4885GRM5 3194/4885
US-20170260219-A1 PHOSPHONATE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS CFD, TFPI, C1QBP CCR1 1999/4885CCR8 3451/4885GRM5 3194/4885
US-20230022157-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT FACTOR D MEDICAL DISORDERS CFD, CFH, TFPI CCR1 1760/4885CCR8 2053/4885GRM5 3955/4885
US-20170298085-A1 CARBAMATE, ESTER, AND KETONE COMPOUNDS FOR TREATMENT OF COMPLEMENT MEDIATED DISORDERS CFD, C9, CFH CCR1 480/4885CCR8 1140/4885GRM5 3846/4885
US-20120101103-A1 7-PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES PTGDR2, PTGDR, HRH2 CCR1 133/4885CCR8 151/4885GRM5 937/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.