Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.80 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.80 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.80 |
| ▸ | HTR1A | P08908 | 1/20 | 0.80 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.80 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.80 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.80 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.80 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.80 |
| ▸ | DRD1 | P21728 | 1/20 | 0.80 |
| ▸ | DRD4 | P21917 | 1/20 | 0.80 |
| ▸ | HRH2 | P25021 | 1/20 | 0.80 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.80 |
| ▸ | HTR2A | P28223 | 1/20 | 0.80 |
| ▸ | HTR2C | P28335 | 1/20 | 0.80 |
| ▸ | HTR7 | P34969 | 1/20 | 0.80 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13284387 | 0.92 | DRD2 (0.67) | DRD2ADRA2ALMNACHRM2CHRM4 | |
| SCHEMBL13284556 | 0.90 | DRD2 (0.80) | DRD2ADRA2ALMNACHRM2CHRM4 | |
| SCHEMBL141875 | 0.89 | ADRA2A (0.81) | DRD2ADRA2ALMNACHRM2CHRM4 | |
| SCHEMBL29549271 | 0.89 | ADRA2A (0.81) | DRD2ADRA2ALMNACHRM2CHRM4 | |
| Quetiapine SCHEMBL7932 | 0.89 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2CHRM4 | |
| Quetiapine SCHEMBL4283801 | 0.89 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2CHRM4 | |
| Quetiapine SCHEMBL29360153 | 0.89 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2CHRM4 | |
| Quetiapine SCHEMBL4638768 | 0.89 | DRD2 (1.00) | DRD2ADRA2ALMNACHRM2CHRM4 | |
| Quetiapine SCHEMBL2537668 | 0.88 | DRD2 (0.94) | DRD2ADRA2ALMNACHRM2CHRM4 | |
| Quetiapine SCHEMBL396057 | 0.88 | DRD2 (0.98) | DRD2ADRA2ALMNACHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095217-A1 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2012-04-19 | — | — | US | disclosed |
| US-20120095217-A1 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2012-04-19 | — | — | US | disclosed |
| WO-2010081036-A2 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095217-A1 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | FLI1, CDC73, FOS | DRD2 2857/4885ADRA2A 4623/4885LMNA 1375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.