SCHEMBL261967

SCHEMBL261967

COc1ccc(C(OC[C@H]2O[C@@H](n3cc(C)c(NC(=O)c4ccccc4)nc3=O)C[C@@H]2O)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TYMP P19971 2/20 0.46
TYMS P04818 1/20 0.40
POLB P06746 1/20 0.40
TMIGD3 P0DMS9 2/20 0.39
ADORA3 P0DMS8 2/20 0.37
ADORA1 P30542 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22984016 1.00 TYMP (0.46) TYMPTYMSPOLBTMIGD3ADORA3
SCHEMBL21828786 1.00 TYMP (0.46) TYMPTYMSPOLBTMIGD3ADORA3
SCHEMBL21504687 0.92 POLB (0.40) TYMPPOLBTMIGD3ADORA3ADORA1
SCHEMBL3510681 0.89 TYMP (0.43) TYMPTYMSPOLBTMIGD3ADORA3
SCHEMBL3510678 0.89 TYMP (0.43) TYMPTYMSPOLBTMIGD3ADORA3
SCHEMBL22983996 0.89 POLB (0.40) TYMPPOLBTMIGD3ADORA3ADORA1
SCHEMBL6274851 0.88 TYMP (0.39) TYMPPOLB
SCHEMBL7069679 0.88 TYMP (0.42) TYMPTYMSPOLBTMIGD3ADORA3
SCHEMBL7069682 0.88 TYMP (0.42) TYMPTYMSPOLBTMIGD3ADORA3
SCHEMBL21473350 0.87 ABL1 (0.47) TYMPTMIGD3ADORA3ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 586 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4741411-A2 OLIGONUCLEOTIDE PRODUCTION METHOD, AND NUCLEOSIDE, NUCLEOTIDE, OR OLIGONUCLEOTIDE AJINOMOTO CO., INC. (JP) 2026-05-13 EP disclosed
US-12269841-B2 Production method for oligonucleotides AJINOMOTO CO., INC. (JP) 2025-04-08 US disclosed
CN-113631564-B Method for producing oligonucleotide having phosphorothioate site 味之素株式会社 2025-02-25 CN disclosed
CN-119431453-A Phosphorus (V) based reagent, method for the production thereof, and use thereof for producing stereoregular organic phosphorus (V) compounds 百时美施贵宝公司 2025-02-14 CN disclosed
CN-112236438-B Phosphorus (V) based reagent, method for the production thereof, and use thereof for producing stereoregular organic phosphorus (V) compounds 百时美施贵宝公司 2024-10-15 CN disclosed
US-12077558-B2 Phosphorus (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophosphorus (V) compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2024-09-03 US disclosed
US-20240018180-A1 OLIGONUCLEOTIDE PRODUCTION METHOD AJINOMOTO CO., INC. (JP) 2024-01-18 US disclosed
US-11859186-B2 Antisense oligonucleotides useful in treatment of Pompe disease ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM (NL) 2024-01-02 US disclosed
EP-4293035-A1 OLIGONUCLEOTIDE PRODUCTION METHOD AJINOMOTO CO., INC. (JP) 2023-12-20 EP disclosed
CN-116888136-A Method for preparing oligonucleotides 味之素株式会社 2023-10-13 CN disclosed
US-20030225256-A1 Antisense modulation of pctaire protein kinase 2 expression ISIS PHARMACEUTICALS INC. 2003-12-04 US disclosed
US-20030225015-A1 Antisense modulation of Rb2/p130 expression ISIS PHARMACEUTICALS INC. 2003-12-04 US disclosed
US-20030225019-A1 Notch1 inhibitors for inducing apoptosis ISIS PHARMACEUTICALS, INC. 2003-12-04 US disclosed
WO-2003100017-A2 OLIGONUCLEOTIDES HAVING MODIFIED NUCLEOSIDE UNITS ISIS PHARMACEUTICALS, INC. (US) 2003-12-04 WO disclosed
US-20030224517-A1 Antisense modulation of beta-site APP-cleaving enzyme 2 expression ISIS PHARMACEUTICALS INC. 2003-12-04 US disclosed
US-20030219895-A1 An oligonucleotide or a hybrids for encoding a protein kinase ISIS PHARMACEUTICALS INC. 2003-11-27 US disclosed
US-20030220273-A1 Antisense modulation of phosphodiesterase 4D expression ISIS PHARMACEUTICALS INC. 2003-11-27 US disclosed
US-20030212017-A1 Antisense modulation of farnesyl transferase beta subunit expression ISIS PHARMACEUTICALS INC. 2003-11-13 US disclosed
US-20030211606-A1 Antisense modulation of DYRK4 expression ISIS PHARMACEUTICALS INC. 2003-11-13 US disclosed
US-20030198965-A1 Antisense modulation of hydroxysteroid 11-beta dehydrogenase 1 expression ISIS PHARMACEUTICALS INC. 2003-10-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12077558-B2 Phosphorus (V)-based reagents, processes for the preparation thereof, and their use in making stereo-defined organophosphorus (V) compounds PPIP5K2, PLCB3, PLCG2 TYMP 96/4885TYMS 1028/4885POLB 1063/4885
US-20240018180-A1 OLIGONUCLEOTIDE PRODUCTION METHOD RNGTT, NOX4, POLRMT TYMP 101/4885TYMS 239/4885POLB 30/4885
US-12269841-B2 Production method for oligonucleotides RNGTT, DCLRE1B, PHOSPHO1 TYMP 30/4885TYMS 98/4885POLB 17/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.