Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 7/20 | 0.63 |
| ▸ | ADAMTS4 | O75173 | 2/20 | 0.63 |
| ▸ | MMP13 | P45452 | 2/20 | 0.63 |
| ▸ | MMP14 | P50281 | 2/20 | 0.63 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.63 |
| ▸ | CA12 | O43570 | 5/20 | 0.59 |
| ▸ | CA1 | P00915 | 5/20 | 0.59 |
| ▸ | CA2 | P00918 | 5/20 | 0.59 |
| ▸ | CA9 | Q16790 | 5/20 | 0.59 |
| ▸ | MMP1 | P03956 | 1/20 | 0.58 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | PGR | P06401 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881270 | 0.84 | ALDH1A1 (0.68) | CA1CA2KMT2AALDH1A1LMNA | |
| SCHEMBL26212913 | 0.81 | MMP2 (0.60) | MMP2MMP13MMP14MMP1MEP1B | |
| SCHEMBL4521900 | 0.80 | ALDH1A1 (0.74) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL10029061 | 0.80 | MMP2 (0.63) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL12499028 | 0.80 | ALDH1A1 (0.75) | MMP2MMP13CA1CA2MMP1 | |
| SCHEMBL20282176 | 0.79 | MMP2 (0.64) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL10029067 | 0.79 | MMP2 (0.64) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL10029063 | 0.79 | MMP2 (0.64) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL5271298 | 0.78 | MMP2 (0.56) | MMP2ADAMTS4MMP13MMP14ADAMTS5 | |
| SCHEMBL26212911 | 0.77 | L3MBTL1 (0.56) | MMP2MMP14MMP1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115843271-B | Indole derivatives and their use for the treatment of cancer | 克洛德贝纳尔-里昂第一大学 | 2024-08-13 | — | — | CN | disclosed |
| US-20230278983-A1 | INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER | UNIVERSITE CLAUDE BERNARD LYON 1 (FR) | 2023-09-07 | — | — | US | disclosed |
| US-20230278983-A1 | INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER | UNIVERSITE CLAUDE BERNARD LYON 1 (FR) | 2023-09-07 | — | — | US | disclosed |
| CN-115843271-A | Indole derivatives and their use for the treatment of cancer | 克洛德贝纳尔-里昂第一大学 | 2023-03-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278983-A1 | INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER | CSNK2A1, IDO1, CSNK2A3 | MMP2 2564/4885ADAMTS4 3594/4885MMP13 3108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.