SCHEMBL2633244

SCHEMBL2633244

CCC(=O)c1ccccc1C(C)=O

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.45
L3MBTL1 Q9Y468 3/20 0.45
MAPT P10636 2/20 0.45
LMNA P02545 4/20 0.44
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 3/20 0.44
HSP90AB1 P08238 1/20 0.44
TSHR P16473 2/20 0.43
PDK2 Q15119 1/20 0.41
KMT2A Q03164 3/20 0.41
TP53 P04637 1/20 0.41
POLB P06746 1/20 0.41
MEN1 O00255 1/20 0.40
ABCB1 P08183 1/20 0.40
ESR1 P03372 1/20 0.39
ITGB3 P05106 1/20 0.39
ITGA2B P08514 1/20 0.39
HMGB1 P09429 1/20 0.39
HPGD P15428 1/20 0.39
GGT1 P19440 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13990159 0.91 L3MBTL1 (0.52) SMN1; SMN2L3MBTL1MAPTALDH1A1HSP90AB1
SCHEMBL13451780 0.85 PDK2 (0.45) SMN1; SMN2L3MBTL1MAPTLMNAALDH1A1
SCHEMBL11373632 0.85 ALDH1A1 (0.50) SMN1; SMN2L3MBTL1MAPTLMNAALDH1A1
SCHEMBL10229644 0.83 LMNA (0.50) SMN1; SMN2L3MBTL1MAPTLMNAALDH1A1
SCHEMBL279655 0.83 ALDH1A1 (0.53) SMN1; SMN2L3MBTL1MAPTLMNAALDH1A1
SCHEMBL4249140 0.82 ALDH1A1 (0.64) SMN1; SMN2L3MBTL1MAPTALDH1A1KDM4E
SCHEMBL26349859 0.81 CNR1 (0.47) SMN1; SMN2L3MBTL1MAPTALDH1A1KDM4E
SCHEMBL7833654 0.80 ALDH1A1 (0.50) SMN1; SMN2L3MBTL1MAPTLMNAALDH1A1
SCHEMBL7596837 0.80 ALDH1A1 (0.50) SMN1; SMN2L3MBTL1MAPTLMNAALDH1A1
SCHEMBL9008317 0.80 ALDH1A1 (0.50) SMN1; SMN2L3MBTL1MAPTLMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111233639-A Preparation method of 4,4' -dihydroxy diphenyl ether 甘肃金盾化工有限责任公司 2020-06-05 CN claimed
US-20240207267-A1 (R)-Glutarimide CRBN Ligands and Methods of Use BEIGENE SWITZERLAND GMBH (CH) 2024-06-27 US disclosed
US-20240190899-A1 ORGANIC COMPOUND, OPTO-ELECTRONIC DEVICE, ELECTRONIC APPARATUS, AND ELECTRONIC DEVICE SAMSUNG DISPLAY CO LTD (KR) 2024-06-13 US disclosed
CN-117939904-A Organic compound, electro-optical device, electronic apparatus, and electronic device 三星显示有限公司 2024-04-26 CN disclosed
US-20240025902-A1 BIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF EGFR AND RELATED METHODS OF USE BEONE MEDICINES I GMBH (CH) 2024-01-25 US disclosed
US-20230265116-A1 DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE BEONE MEDICINES I GMBH (CH) 2023-08-24 US disclosed
US-20230248834-A1 DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE BEONE MEDICINES I GMBH (CH) 2023-08-10 US disclosed
US-20230034284-A1 FUNCTIONALIZED N-ACETYLGALACTOSAMINE NUCLEOSIDES HONGENE BIOTECH CORPORATION 2023-02-02 US disclosed
CN-111233639-B Preparation method of 4,4' -dihydroxy diphenyl ether 甘肃金盾化工有限责任公司 2022-08-26 CN disclosed
US-20200283417-A1 AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA UNIVERSITY OF MARYLAND, BALTIMORE 2020-09-10 US disclosed
US-20150187589-A1 HARDMASK COMPOSITION AND METHOD OF FORMING PATTERNS USING THE HARDMASK COMPOSITION SAMSUNG SDI CO., LTD. (KR) 2015-07-02 US disclosed
WO-2015087993-A1 OXAZOLIDINE AND OXAZINANE DERIVATIVES 大正製薬株式会社 2015-06-18 WO disclosed
US-8158454-B2 Method for manufacturing solar cell module SANYO ELECTRIC CO., LTD. (JP) 2012-04-17 US disclosed
WO-2012000598-A1 METHOD FOR THE PREPARATION OF CIS-1,2-DIOLS IN THE KILOGRAM SCALE MERCK PATENT GMBH (DE) 2012-01-05 WO disclosed
EP-1630213-B2 Ink-jet ink set and recording method using the same KONICA MINOLTA MED & GRAPHIC (JP) 2011-08-17 EP disclosed
EP-1730142-B1 NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS SCHERING CORP (US) 2011-06-29 EP disclosed
US-20100255631-A1 METHOD FOR MANUFACTURING SOLAR CELL MODULE SANYO ELECTRIC CO., LTD. (JP) 2010-10-07 US disclosed
US-7645771-B2 CCR5 antagonists as therapeutic agents SMITHKLINE BEECHAM CORP. (US) 2010-01-12 US disclosed
CN-1097073-C Polymer composition and resist meterial WAKO PURE CHEM IND LTD (JP) 2002-12-25 CN disclosed
CN-1159459-A Polymer composition and resist meterial WAKO PURE CHEM IND LTD (JP) 1997-09-17 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230265116-A1 DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE EGFR, CBL, ERBB2 SMN1; SMN2 4590/4885L3MBTL1 1119/4885MAPT 3181/4885
US-20240207267-A1 (R)-Glutarimide CRBN Ligands and Methods of Use CRBN, CDR2, CRKL SMN1; SMN2 2282/4885L3MBTL1 2113/4885MAPT 2667/4885
US-20240025902-A1 BIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF EGFR AND RELATED METHODS OF USE EGFR, ERBB2, CBL SMN1; SMN2 4489/4885L3MBTL1 882/4885MAPT 3520/4885
US-20230248834-A1 DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE EGFR, CBL, ERBB2 SMN1; SMN2 4590/4885L3MBTL1 1119/4885MAPT 3181/4885
US-20200283417-A1 AZIRIDINYL AND AMINO DIMERIC NAPHTHOQUINONE COMPOUNDS AND USE FOR ACUTE MYELOID LEUKEMIA MCL1, NPM1, ABL1 SMN1; SMN2 3156/4885L3MBTL1 4653/4885MAPT 4723/4885
US-20240190899-A1 ORGANIC COMPOUND, OPTO-ELECTRONIC DEVICE, ELECTRONIC APPARATUS, AND ELECTRONIC DEVICE CYBB, CYBA, PPOX SMN1; SMN2 4471/4885L3MBTL1 4713/4885MAPT 3553/4885
US-20230034284-A1 FUNCTIONALIZED N-ACETYLGALACTOSAMINE NUCLEOSIDES FUT6, B3GNT2, GALNT6 SMN1; SMN2 1428/4885L3MBTL1 662/4885MAPT 3248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.