SCHEMBL4249140

SCHEMBL4249140

CCC(=O)c1ccccc1C(=O)O

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.64
ALOX15 P16050 1/20 0.64
USP2 O75604 1/20 0.51
TP53 P04637 1/20 0.51
TDP1 Q9NUW8 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
AKR1C3 P42330 2/20 0.50
MAPT P10636 2/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
KDM4E B2RXH2 2/20 0.48
HMGB1 P09429 2/20 0.48
HPGD P15428 2/20 0.48
NAPRT Q6XQN6 2/20 0.48
ESR1 P03372 1/20 0.48
ITGB3 P05106 1/20 0.48
ITGA2B P08514 1/20 0.48
TSHR P16473 1/20 0.48
GGT1 P19440 1/20 0.48
PTGS1 P23219 1/20 0.48
PTGS2 P35354 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13990159 0.91 L3MBTL1 (0.52) ALDH1A1ALOX15TP53TDP1SMN1; SMN2
Phthalic Acid SCHEMBL28107851 0.86 ALDH1A1 (0.70) ALDH1A1ALOX15TDP1SMN1; SMN2AKR1C3
Phthalic Acid SCHEMBL122971 0.86 ALDH1A1 (0.70) ALDH1A1ALOX15TDP1SMN1; SMN2AKR1C3
Phthalic Acid SCHEMBL27458631 0.85 ALDH1A1 (0.78) ALDH1A1ALOX15TDP1SMN1; SMN2AKR1C3
SCHEMBL28738497 0.85 MYC (0.52) ALDH1A1ALOX15TDP1SMN1; SMN2MAPT
Phthalic Acid SCHEMBL3030281 0.84 ALDH1A1 (0.67) ALDH1A1ALOX15TDP1SMN1; SMN2AKR1C3
Phthalic Acid SCHEMBL1482851 0.83 ALDH1A1 (0.74) ALDH1A1ALOX15TP53TDP1SMN1; SMN2
Phthalic Acid SCHEMBL10779822 0.83 ALDH1A1 (0.74) ALDH1A1ALOX15TDP1SMN1; SMN2AKR1C3
Phthalic Acid SCHEMBL9132518 0.83 ALDH1A1 (0.74) ALDH1A1ALOX15TP53TDP1SMN1; SMN2
SCHEMBL9533934 0.83 ALDH1A1 (0.58) ALDH1A1ALOX15USP2TP53TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104419326-A Slurry composition for chemical mechanical polishing COWON INNOTECH INC 2015-03-18 CN claimed
CN-118619905-A Butylphthalide derivative, preparation method and application thereof 河南真实生物科技有限公司 2024-09-10 CN disclosed
CN-218012756-U 2-ethyl anthraquinone production system capable of reducing dissolution closed-loop acid consumption 百色世裕科技股份有限公司 2022-12-13 CN disclosed
EP-3218009-B1 PROCESS FOR THE CONJUGATION OF A PEPTIDE OR PROTEIN WITH A REAGENT COMPRISING A LEAVING GROUP INCLUDING A PORTION OF PEG POLYTHERICS LTD (GB) 2021-04-07 EP disclosed
CN-107949596-B Semi-crystalline polyamide component with high glass transition temperature for composite materials, method for the production thereof and use thereof 阿科玛法国公司 2021-02-02 CN disclosed
CN-108026267-B Semi-crystalline polyamide composition with high glass transition temperature for thermoplastic materials, method for the production thereof and use thereof 阿科玛法国公司 2021-02-02 CN disclosed
US-10835616-B2 Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of PEG POLYTHERICS LIMITED (GB) 2020-11-17 US disclosed
US-20180094010-A1 TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE NEWGEN THERAPEUTICS INC (US) 2018-04-05 US disclosed
US-20180081273-A1 RESIN COMPOSITION, METHOD FOR FORMING PATTERN USING THE SAME, AND METHOD FOR SYNTHESIZING POLYMER NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2018-03-22 US disclosed
US-20170363637-A1 Method and Kit for Determining Risk of Preterm Birth and/or Birth of Low-Birth-Weight Baby HIROSHIMA UNIVERSITY (JP) 2017-12-21 US disclosed
US-5780634-A Process for producing 2-(carboxyphenyl)-4-quinolinecarboxylic acid compounds THE GREEN CROSS CORPORATION (JP) 1998-07-14 US disclosed
EP-0709377-A1 Process for producing quinolin-2-yl benzoic acid compounds ASAHI GLASS COMPANY LTD. (JP) 1996-05-01 EP disclosed
US-5264436-A Alpha-adrenoceptors antagonist, hypotensive agents or antidiabetic agents BEECHAM GROUP P.L.C. (GB) 1993-11-23 US disclosed
EP-0275639-B1 N-SUBSTITUTED CYCLIC AMIDES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM BEECHAM GROUP PLC (GB) 1992-07-15 EP disclosed
US-5077299-A Glaucoma, antidepressants, anticoagulants, hypotensive agents BEECHAM GROUP P.L.C. (GB) 1991-12-31 US disclosed
US-4918083-A 4,5 Dihydroimidazole compounds which have useful pharmaceutical utility BEECHAM GROUP P.L.C. (GB) 1990-04-17 US disclosed
EP-0274906-A2 Method for the production of crosslinked olefinic block copolymers MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1988-07-20 EP disclosed
US-4351842-A N-Cyclopropylisoindolines GLAXO LABORATORIES LIMITED (GB) 1982-09-28 US disclosed
US-4058529-A Polycyclic amino derivatives of pyrrolidone and piperidone CIBA-GEIGY CORPORATION (US) 1977-11-15 US disclosed
US-3994920-A APPETITE SUPPRESSANT, ANTIDEPRESSANT AMERICAN HOME PRODUCTS CORPORATION (US) 1976-11-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170363637-A1 Method and Kit for Determining Risk of Preterm Birth and/or Birth of Low-Birth-Weight Baby LGALS3, LGALS3BP, LGALS1 ALDH1A1 3283/4885ALOX15 2696/4885USP2 3220/4885
US-10835616-B2 Process for the conjugation of a peptide or protein with a reagent comprising a leaving group including a portion of PEG LNPEP, ANPEP, NGLY1 ALDH1A1 3963/4885ALOX15 2780/4885USP2 125/4885
US-20180094010-A1 TRICYCLIC INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE PARP1, PARP2, PARP11 ALDH1A1 1069/4885ALOX15 441/4885USP2 3277/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.