Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22200913 | 0.81 | TSHR (0.47) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL26367637 | 0.73 | VCP (0.55) | VCP | |
| SCHEMBL12647572 | 0.69 | GRM1 (0.49) | ALDH1A1GRM1CYP2A6CYP2E1MAPT | |
| SCHEMBL13114037 | 0.67 | HTT (0.30) | ALDH1A1HTTNPSR1 | |
| SCHEMBL22189959 | 0.66 | NPC1 (0.43) | ALDH1A1CYP3A4CYP2C9CYP2C19NPSR1 | |
| SCHEMBL4884791 | 0.64 | CYP2A6 (0.53) | ALDH1A1CYP2A6CYP3A4CYP2E1ALOX12 | |
| SCHEMBL19764009 | 0.64 | TRPV1 (0.44) | ALDH1A1HTTNPSR1HPGDKDM4E | |
| SCHEMBL5648367 | 0.64 | CYP2A6 (0.62) | ALDH1A1CYP2A6CYP3A4CYP2E1HTT | |
| SCHEMBL15444712 | 0.64 | HTR3A (0.57) | CYP2A6CYP3A4CYP2E1HTTKDM4E | |
| SCHEMBL1554748 | 0.64 | ALKBH2 (0.53) | ALDH1A1GRM1CYP2A6HRH3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773075-B2 | Modulators of p97 AAA ATPase activity | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-10-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11773075-B2 | Modulators of p97 AAA ATPase activity | PSMG3, CDC37, AHSA1 | ALDH1A1 3583/4885GRM1 3253/4885CYP2A6 3813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.