Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22189959 | 0.83 | NPC1 (0.43) | TSHRNPSR1NPC1RAB9AALDH1A1 | |
| SCHEMBL22200914 | 0.82 | RAB9A (0.43) | TSHRNPSR1NPC1RAB9AALDH1A1 | |
| SCHEMBL4035995 | 0.82 | IDO1 (0.49) | NPSR1NPC1RAB9AALDH1A1GAA | |
| SCHEMBL26367604 | 0.81 | ALDH1A1 (0.40) | TSHRNPSR1RAB9AALDH1A1CYP3A4 | |
| SCHEMBL14249281 | 0.80 | POLB (0.47) | TSHRNPSR1NPC1RAB9AALDH1A1 | |
| SCHEMBL22189958 | 0.79 | NPC1 (0.41) | TSHRNPSR1NPC1RAB9AALDH1A1 | |
| SCHEMBL2543314 | 0.77 | ALDH1A1 (0.43) | TSHRNPSR1NPC1RAB9AALDH1A1 | |
| SCHEMBL22200950 | 0.77 | VCP (0.52) | — | |
| SCHEMBL11004197 | 0.76 | NOD2 (0.50) | TSHRNPSR1NPC1RAB9AALDH1A1 | |
| SCHEMBL20027831 | 0.74 | ALDH1A1 (0.53) | TSHRNPSR1NPC1RAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11773075-B2 | Modulators of p97 AAA ATPase activity | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2023-10-03 | — | — | US | disclosed |
| US-20220089565-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-03-24 | — | — | US | disclosed |
| US-11214560-B2 | Modulators of P97 AAA ATPase activity | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-01-04 | — | — | US | disclosed |
| US-20200216410-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089565-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | PSMG3, CDC37, AHSA1 | TSHR 4843/4885NPSR1 4656/4885NPC1 602/4885 |
| US-20200216410-A1 | MODULATORS OF P97 AAA ATPASE ACTIVITY | PSMG3, AHSA1, CDC37 | TSHR 4841/4885NPSR1 4605/4885NPC1 719/4885 |
| US-11214560-B2 | Modulators of P97 AAA ATPase activity | PSMG3, AHSA1, CDC37 | TSHR 4841/4885NPSR1 4605/4885NPC1 719/4885 |
| US-11773075-B2 | Modulators of p97 AAA ATPase activity | PSMG3, CDC37, AHSA1 | TSHR 4843/4885NPSR1 4656/4885NPC1 602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.