Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637571 | 0.89 | ALDH1A1 (0.50) | FFAR4MAPTPOLBKDM4EALDH1A1 | |
| SCHEMBL2637663 | 0.89 | PGR (0.42) | FFAR4MAPTTP53SMN1; SMN2POLB | |
| SCHEMBL2637590 | 0.74 | KDM4E (0.41) | MAPTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2637722 | 0.73 | PSD (0.39) | MAPTTP53SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2637795 | 0.72 | MEN1 (0.44) | MAPTTP53SMN1; SMN2POLBKDM4E | |
| SCHEMBL3412133 | 0.71 | KEAP1 (0.46) | MAPTSMN1; SMN2POLBALDH1A1GAA | |
| SCHEMBL2637556 | 0.71 | POLB (0.46) | MAPTSMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL2637889 | 0.70 | KMT2A (0.46) | MAPTPOLBKDM4EALDH1A1HPGD | |
| SCHEMBL2638047 | 0.69 | KDM4A (0.44) | MAPTTP53SMN1; SMN2POLBKDM4E | |
| SCHEMBL2637595 | 0.68 | MAPT (0.43) | MAPTTP53SMN1; SMN2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |