Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637577 | 0.82 | MAPT (0.53) | PDE3BPDE3ASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL2637269 | 0.79 | SLC22A12 (0.41) | PDE3BPDE3ASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL2637483 | 0.74 | PLAT (0.43) | SMN1; SMN2KMT2AKDM4EMAPTL3MBTL1 | |
| SCHEMBL2637603 | 0.73 | ALOX5 (0.48) | PDE3BPDE3ASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL3407318 | 0.72 | ALDH1A1 (0.53) | SMN1; SMN2KMT2ANPC1RAB9AKDM4E | |
| SCHEMBL2638131 | 0.72 | ALDH1A1 (0.43) | SMN1; SMN2KMT2AKDM4EMAPTPOLB | |
| SCHEMBL2637787 | 0.72 | PLAT (0.42) | SMN1; SMN2KMT2AKDM4EMAPTL3MBTL1 | |
| SCHEMBL11553029 | 0.69 | ALOX5 (0.54) | PDE3BPDE3ASMN1; SMN2KDM4ETDP1 | |
| SCHEMBL5309082 | 0.68 | KDM5A (0.58) | GABRA1GABRB1GABRA3GABRB2CSF1R | |
| SCHEMBL3262242 | 0.68 | SMN1; SMN2 (0.56) | PDE3BPDE3ASMN1; SMN2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438070-A1 | GLYCINE B ANTAGONISTS | Merz Pharma GmbH & Co. KGaA (DE) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139483-A1 | GLYCINE B ANTAGONISTS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-12-09 | — | — | WO | disclosed |