SCHEMBL2640103

SCHEMBL2640103

O=C(O)O[C@@H]1CCCN1C(=O)c1ccc(Cl)s1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.52
HPGD P15428 1/20 0.52
MAPT P10636 2/20 0.45
MMP8 P22894 1/20 0.43
MMP12 P39900 1/20 0.43
MMP13 P45452 1/20 0.43
DAO P14920 1/20 0.42
TSHR P16473 2/20 0.41
RAB9A P51151 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
NPC1 O15118 1/20 0.41
TP53 P04637 1/20 0.41
POLB P06746 1/20 0.41
L3MBTL1 Q9Y468 3/20 0.41
F10 P00742 2/20 0.40
F2 P00734 1/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA7 P43166 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6290811 0.79 L3MBTL1 (0.57) ALDH1A1HPGDMAPTMMP8MMP12
SCHEMBL6290809 0.79 L3MBTL1 (0.57) ALDH1A1HPGDMAPTMMP8MMP12
SCHEMBL7009968 0.72 KDM4E (0.49) ALDH1A1HPGDNPC1POLBL3MBTL1
SCHEMBL7002023 0.72 HSD11B1 (0.46) ALDH1A1HPGDRAB9ANPC1L3MBTL1
SCHEMBL1031822 0.71 EGLN1 (0.44) MAPT
SCHEMBL1032206 0.71 EGLN1 (0.44) MAPT
SCHEMBL4028654 0.70 ALDH1A1 (0.53) ALDH1A1HPGDMAPTDAOTSHR
SCHEMBL2567470 0.70 ALDH1A1 (0.46) ALDH1A1HPGDMAPTDAOTSHR
SCHEMBL10509618 0.70 SPR (0.46) ALDH1A1SMN1; SMN2GAA
SCHEMBL5161696 0.69 SMN1; SMN2 (0.53) MAPTRAB9ASMN1; SMN2NPC1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4705015-B2 2011-06-22 JP claimed
EP-1791597-A2 CARBONYL COMPOUND-CONTAINING DRUG AND THE USE THEREOF Merck Patent GmbH (DE) 2007-06-06 EP claimed
EP-1720844-A2 PYRROLIDINO-1,2-DICARBOXY-1-(PHENYLAMIDE)-2-(4-(3-OXO-MORPHOLINO-4-YL)-PHENYLAMIDE) DERIVATIVES AND RELATED COMPOUNDS FOR USE AS INHIBITORS OF COAGULATION FACTOR XA IN THE TREATMENT OF THROMBO-EMBOLIC DISEASES MERCK PATENT GmbH (DE) 2006-11-15 EP claimed
JP-2006522033-A 2006-09-28 JP claimed
WO-2006032342-A2 CARBONYL COMPOUND-CONTAINING DRUG AND THE USE THEREOF MERCK PATENT GMBH (DE) 2006-03-30 WO claimed
WO-2004087646-A2 PYRROLIDINO-1,2-DICARBOXY-1-(PHENYLAMIDE)-2-(4-(3-OXO-MORPHOLINO-4-YL)-PHENYLAMIDE) DERIVATIVES AND RELATED COMPOUNDS FOR USE AS INHIBITORS OF COAGULATION FACTOR XA IN THE TREATMENT OF THROMBO-EMBOLIC DISEASES MERCK PATENT GMBH (DE) 2004-10-14 WO claimed