Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | UPP1 | Q16831 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26404316 | 0.86 | ALDH1A1 (0.46) | ALDH1A1TSHRKDM4EATMUPP1 | |
| SCHEMBL20340026 | 0.82 | ALDH1A1 (0.40) | ALDH1A1TSHRKDM4EATMUPP1 | |
| SCHEMBL26403864 | 0.80 | KDM4E (0.51) | ALDH1A1TSHRKDM4EUPP1GAA | |
| SCHEMBL12818167 | 0.74 | ALDH1A1 (0.78) | ALDH1A1TSHRKDM4EUPP1GAA | |
| SCHEMBL26404304 | 0.73 | HSD11B1 (0.34) | ALDH1A1TSHRKDM4EGAACXCR2 | |
| SCHEMBL20339960 | 0.71 | KDM4E (0.38) | ALDH1A1KDM4EGAACXCR2HSD11B1 | |
| SCHEMBL20350982 | 0.68 | TSHR (0.40) | ALDH1A1TSHRKDM4EATMUPP1 | |
| SCHEMBL20350899 | 0.68 | ALDH1A1 (0.39) | ALDH1A1TSHRKDM4EATMUPP1 | |
| SCHEMBL1086023 | 0.67 | UPP1 (0.53) | ALDH1A1KDM4EATMUPP1GAA | |
| SCHEMBL26403858 | 0.67 | KDM4E (0.52) | ALDH1A1KDM4EATMUPP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ORSOBIO, INC. (US) | 2023-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780812-B2 | Oxopyridine derivatives useful as aminocarboxymuconate semialdehyde decarboxylase (ACMSD) inhibitors | ALDH7A1, ACMSD, AMD1 | ALDH1A1 370/4885TSHR 4389/4885KDM4E 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.