Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | UBE2M | P61081 | 2/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26408685 | 0.87 | TP53 (0.44) | POLBMAPTMGLL | |
| SCHEMBL26408701 | 0.87 | NPSR1 (0.49) | UBE2MDCUN1D1KDM4ENPSR1USP2 | |
| SCHEMBL26408941 | 0.86 | MALT1 (0.36) | MAPT | |
| SCHEMBL26408052 | 0.85 | LMNA (0.45) | LMNAACKR3 | |
| SCHEMBL26408062 | 0.85 | LMNA (0.43) | LMNAUBE2MDCUN1D1ACKR3KDM4E | |
| SCHEMBL26408695 | 0.85 | SMN1; SMN2 (0.48) | KDM4ESMN1; SMN2NPSR1GAAMAPT | |
| SCHEMBL26408686 | 0.84 | MAPT (0.43) | LMNAGAAHTTPOLBMAPT | |
| SCHEMBL26408696 | 0.83 | SMN1; SMN2 (0.47) | LMNAKDM4ESMN1; SMN2NPSR1GAA | |
| SCHEMBL26408699 | 0.83 | MALT1 (0.47) | SMN1; SMN2GAAHPGDHTT | |
| SCHEMBL26408707 | 0.81 | MGLL (0.43) | LMNASMN1; SMN2HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192675-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIRONONANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |