Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 7/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26408695 | 0.91 | SMN1; SMN2 (0.48) | SMN1; SMN2ALDH1A1TP53NPSR1GAA | |
| SCHEMBL26408701 | 0.87 | NPSR1 (0.49) | ALDH1A1NPSR1HSD17B10KDM4EMEN1 | |
| SCHEMBL26408685 | 0.85 | TP53 (0.44) | ALDH1A1TP53MAPTPOLBKMT2A | |
| SCHEMBL26408693 | 0.83 | LMNA (0.41) | SMN1; SMN2HTTLMNANPSR1GAA | |
| SCHEMBL26408686 | 0.82 | MAPT (0.43) | ALDH1A1HTTTP53LMNAGAA | |
| SCHEMBL26408251 | 0.81 | CACNA1H (0.43) | SMN1; SMN2ALDH1A1TP53LMNAMAPT | |
| SCHEMBL26408948 | 0.81 | SIGMAR1 (0.47) | MAPTPOLBHCRTR1HCRTR2 | |
| SCHEMBL26408937 | 0.80 | HRH2 (0.40) | SMN1; SMN2ALDH1A1LMNANPSR1POLB | |
| SCHEMBL26409305 | 0.80 | CACNA1H (0.42) | SMN1; SMN2ALDH1A1TP53LMNAMAPT | |
| SCHEMBL26408941 | 0.80 | MALT1 (0.36) | MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192675-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING AN AZASPIRONONANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |