Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2641159 | 0.85 | NPC1 (0.41) | NPC1RAB9AGFERACHEHDAC1 | |
| SCHEMBL1947345 | 0.80 | DRD2 (0.45) | NPC1RAB9AGFERACHEHDAC1 | |
| SCHEMBL2641013 | 0.75 | PTPN11 (0.41) | LMNAPOLBGAAHSD17B3THRB | |
| SCHEMBL3415407 | 0.74 | HSD11B1 (0.45) | RAB9ANTRK1MAPTPPARAL3MBTL1 | |
| SCHEMBL3262613 | 0.73 | HDAC4 (0.45) | NPC1RAB9ANTRK1HDAC4LMNA | |
| SCHEMBL2640599 | 0.72 | PARP1 (0.43) | NPC1RAB9AGFERLMNA | |
| SCHEMBL1951356 | 0.71 | RAB9A (0.43) | NPC1RAB9AGFERHDAC1LMNA | |
| SCHEMBL1949299 | 0.69 | CNR2 (0.38) | NPC1HTR2CHTR2BLMNAPOLB | |
| SCHEMBL6131245 | 0.68 | MAOA (0.46) | NTRK1MAPTGAAHSD17B3 | |
| SCHEMBL1952863 | 0.65 | PARP10 (0.65) | RAB9ANTRK1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2438055-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2012-04-11 | — | — | EP | disclosed |
| WO-2010139967-A1 | DIHYDROINDOLE AND TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS POTASSIUM CHANNEL INHIBITORS | XENTION LIMITED (GB) | 2010-12-09 | — | — | WO | disclosed |