Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA5A | P35218 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2202453 | 0.88 | KDM4E (0.54) | ROCK2ROCK1KMT2AKDM4EKDM4C | |
| SCHEMBL8263373 | 0.79 | ALDH1A1 (0.58) | ROCK2ROCK1KMT2ALMNAMEN1 | |
| SCHEMBL17602099 | 0.76 | FNTA (0.55) | ROCK2ROCK1KMT2AKDM4CCA2 | |
| SCHEMBL5232476 | 0.75 | SRD5A2 (0.51) | ROCK2ROCK1KMT2ALMNAMEN1 | |
| SCHEMBL9998819 | 0.75 | POLQ (0.61) | POLQ | |
| SCHEMBL3884249 | 0.75 | NOTUM (0.56) | ROCK2ROCK1KMT2AKDM4EKDM4C | |
| SCHEMBL8789730 | 0.74 | ALDH1A1 (0.46) | KMT2AKDM4EALDH1A1MAPTPOLQ | |
| SCHEMBL222344 | 0.74 | FASN (0.47) | KMT2AKDM4EGAAABCC4LMNA | |
| SCHEMBL20888587 | 0.74 | LMNA (0.62) | KMT2AKDM4ECA12CA1CA2 | |
| SCHEMBL8699095 | 0.74 | MLYCD (0.64) | KMT2AKDM4EGAALMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230128765-A1 | Small Molecule Activators of Parkin Enzyme Function | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2023-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230128765-A1 | Small Molecule Activators of Parkin Enzyme Function | UCHL1, ADRM1, UCHL5 | ROCK2 2801/4885ROCK1 2873/4885KMT2A 1300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.