Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | PRNP | P04156 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.60 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.60 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.60 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3036074 | 0.84 | KDM4E (0.74) | CYP2C9PRNPCYP1A2CYP2C19PPARG | |
| SCHEMBL8959541 | 0.78 | PRNP (0.69) | CYP2C9PRNPCYP1A2CYP2C19PPARG | |
| SCHEMBL9662514 | 0.77 | PTGS2 (0.54) | PTGS2PTGS1KDM4E | |
| SCHEMBL6286696 | 0.77 | AKR1C2 (0.72) | CYP2C9NPSR1PTGS2PTGS1KDM4E | |
| SCHEMBL3107611 | 0.76 | PRNP (0.71) | CYP2C9PRNPCYP1A2CYP2C19PPARG | |
| SCHEMBL1553071 | 0.76 | NPSR1 (0.71) | CYP2C9PRNPCYP1A2CYP2C19PPARG | |
| SCHEMBL9661003 | 0.76 | GPR17 (0.48) | PTGS2PTGS1ALDH1A1HSD17B10POLB | |
| SCHEMBL31025911 | 0.76 | KIF11 (0.52) | NPSR1PTGS2PTGS1KDM4EALDH1A1 | |
| SCHEMBL1894184 | 0.75 | RXFP1 (1.00) | CYP2C9PRNPCYP1A2CYP2C19PPARG | |
| SCHEMBL2538695 | 0.75 | PRNP (0.69) | CYP2C9PRNPCYP1A2CYP2C19PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598398-B2 | Acyl indoles, compositions containing such compounds and methods of use | MERCK & CO., INC. (US) | 2009-10-06 | — | — | US | disclosed |
| US-20070088071-A1 | Acyl indoles, compositions containing such compounds and methods of use | MERCK SHARP & DOHME LLC | 2007-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070088071-A1 | Acyl indoles, compositions containing such compounds and methods of use | GPR119, IAPP, GLP1R | CYP2C9 3351/4885PRNP 4753/4885CYP1A2 1260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.