Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | PDE5A | O76074 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6035072 | 0.84 | RAB9A (0.49) | RAB9AALDH1A1PDE5ATSHRHPGD | |
| SCHEMBL19327576 | 0.81 | ALDH1A1 (0.51) | RAB9AALDH1A1PDE5ATSHRHPGD | |
| SCHEMBL26602181 | 0.79 | GAA (0.49) | RAB9AALDH1A1L3MBTL1LMNAPOLB | |
| SCHEMBL4721537 | 0.78 | PARP1 (0.57) | RAB9AALDH1A1PDE5ATSHRHPGD | |
| SCHEMBL13235148 | 0.75 | KMT2A (0.68) | RAB9AALDH1A1PDE5ATSHRHPGD | |
| SCHEMBL7081465 | 0.74 | RAB9A (0.46) | RAB9AALDH1A1PDE5ATSHRLMNA | |
| SCHEMBL13456847 | 0.74 | RAB9A (0.52) | RAB9AALDH1A1PDE5ATSHRHPGD | |
| SCHEMBL9491914 | 0.71 | ALDH1A1 (0.54) | RAB9AALDH1A1PDE5ATSHRHPGD | |
| SCHEMBL16728898 | 0.71 | RAB9A (0.52) | RAB9AALDH1A1PDE5ATSHRHPGD | |
| SCHEMBL11286643 | 0.71 | HPGD (0.72) | ALDH1A1HPGDTP53LMNACA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4113731-A | PHOTOGRAPHIC EMULSION STABILIZERS | GRUPPO LEPETIT S.P.A. (IT) | 1978-09-12 | — | — | US | claimed |
| US-6541484-B2 | Central nervous system disorders; psychological disorders | MERCK SHARP & DOHME LIMITED | 2003-04-01 | — | — | US | disclosed |
| US-20030004180-A1 | Pyrazolo-pyridine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-01-02 | — | — | US | disclosed |
| EP-1244659-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001044244-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |
| EP-0005745-B1 | PYRAZOLO (3,4-C) AND THIAZOLO (5,4-C) ISOQUINOLINES, METHODS FOR PREPARING THEM, THESE COMPOUNDS FOR USE AS ANTIINFLAMMATORY, CNS-DEPRESSANT AND ANTI-ANXIETY AGENTS AND PHARMACEUTICAL COMPOSITIONS THEREOF | GRUPPO LEPETIT S.P.A. (IT) | 1982-07-14 | — | — | EP | disclosed |
| US-4232017-A | CNS DEPRESSANTS; TRANQUILIZERS | GRUPPO LEPETIT S.P.A. (IT) | 1980-11-04 | — | — | US | disclosed |
| EP-0005745-A1 | Pyrazolo (3,4-c) and thiazolo (5,4-c) isoquinolines, methods for preparing them, these compounds for use as antiinflammatory, CNS-depressant and anti-anxiety agents and pharmaceutical compositions thereof | GRUPPO LEPETIT S.P.A. (IT) | 1979-12-12 | — | — | EP | disclosed |
| US-4113731-A | PHOTOGRAPHIC EMULSION STABILIZERS | GRUPPO LEPETIT S.P.A. (IT) | 1978-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004180-A1 | Pyrazolo-pyridine derivatives as ligands for gaba receptors | GABRA3, GABRA4, GABRB3 | RAB9A 2107/4885ALDH1A1 1355/4885PDE5A 2136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.