Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26464503 | 0.90 | KCNT1 (0.49) | CACNA1HLMNAMEN1KMT2APOLB | |
| SCHEMBL26464500 | 0.82 | CACNA1H (0.70) | HTTCACNA1HMEN1KMT2ADRD4 | |
| SCHEMBL26465838 | 0.82 | CACNA1H (0.55) | CACNA1HDRD4ALDH1A1 | |
| SCHEMBL26465699 | 0.79 | HPGD (0.55) | HTTCACNA1HLMNATSHRMEN1 | |
| SCHEMBL26464490 | 0.78 | CACNA1H (0.54) | CACNA1H | |
| SCHEMBL26465811 | 0.77 | ALDH1A1 (0.49) | CACNA1HLMNATSHRMEN1KMT2A | |
| SCHEMBL26465833 | 0.76 | CACNA1H (0.56) | CACNA1HLMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL26466388 | 0.76 | KCNT1 (0.47) | HTTCACNA1HLMNATSHRMEN1 | |
| SCHEMBL26464783 | 0.75 | CACNA1H (0.46) | HTTCACNA1HKMT2AL3MBTL1 | |
| SCHEMBL26465992 | 0.71 | CACNA1H (0.49) | CACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |