Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNT1 | Q5JUK3 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 9/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26465710 | 0.90 | HTT (0.50) | CACNA1HPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL26465811 | 0.87 | ALDH1A1 (0.49) | CACNA1HPOLBPKMMEN1KMT2A | |
| SCHEMBL26466388 | 0.86 | KCNT1 (0.47) | KCNT1CACNA1HNPC1ANO1POLB | |
| SCHEMBL26465699 | 0.85 | HPGD (0.55) | CACNA1HMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL26464500 | 0.82 | CACNA1H (0.70) | KCNT1CACNA1HMEN1KMT2A | |
| SCHEMBL26465838 | 0.82 | CACNA1H (0.55) | CACNA1HALDH1A1CACNA1GCACNA1I | |
| SCHEMBL26464490 | 0.82 | CACNA1H (0.54) | CACNA1HANO1CACNA1GCACNA1I | |
| SCHEMBL26464783 | 0.81 | CACNA1H (0.46) | CACNA1HKMT2ACACNA1GCACNA1I | |
| SCHEMBL26465810 | 0.80 | CACNA1H (0.47) | CACNA1HPOLBALDH1A1LMNACACNA1G | |
| SCHEMBL26465812 | 0.80 | CACNA1H (0.47) | CACNA1HPOLBMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192669-A1 | T-TYPE CALCIUM CHANNEL MODULATORS COMPRISING A PIPERAZINE OR 1,4-DIAZEPANE CORE AND METHODS OF USE THEREOF | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-10-05 | — | — | WO | disclosed |