SCHEMBL2646637

SCHEMBL2646637

CCOC(=O)Cc1ccc(Cl)c(Cl)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.60
SMN1; SMN2 Q16637 3/20 0.60
ALOX15 P16050 2/20 0.59
HTT P42858 2/20 0.59
L3MBTL1 Q9Y468 2/20 0.59
CRHBP P24387 1/20 0.59
CRHR2 Q13324 1/20 0.59
SIGMAR1 Q99720 2/20 0.57
CYP1A2 P05177 1/20 0.57
CYP2D6 P10635 1/20 0.57
ALDH1A1 P00352 3/20 0.55
MAPK1 P28482 1/20 0.55
HSD17B10 Q99714 1/20 0.55
KDM4E B2RXH2 2/20 0.53
BLM P54132 1/20 0.53
MAPT P10636 2/20 0.51
CYP4F2 P78329 1/20 0.49
CYP4A11 Q02928 1/20 0.49
KLK7 P49862 1/20 0.48
LMNA P02545 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31441301 1.00 TSHR (0.60) TSHRSMN1; SMN2ALOX15HTTL3MBTL1
SCHEMBL14559833 0.88 L3MBTL1 (0.51) TSHRSMN1; SMN2ALOX15HTTL3MBTL1
SCHEMBL137925 0.87 YWHAG (0.50) TSHRSMN1; SMN2ALOX15HTTL3MBTL1
SCHEMBL1558288 0.87 CA2 (0.60) TSHRSMN1; SMN2ALOX15HTTL3MBTL1
SCHEMBL13742793 0.85 MAPT (0.48) TSHRSMN1; SMN2ALOX15HTTL3MBTL1
SCHEMBL90470 0.85 CYP3A4 (0.49) TSHRSMN1; SMN2ALOX15HTTL3MBTL1
SCHEMBL18524140 0.85 MAPT (0.48) TSHRSMN1; SMN2ALOX15HTTL3MBTL1
SCHEMBL7266886 0.85 ALDH1A1 (0.49) TSHRSMN1; SMN2ALOX15HTTL3MBTL1
SCHEMBL3227920 0.84 POLB (0.49) TSHRSMN1; SMN2ALOX15HTTL3MBTL1
Hydrochloric Acid SCHEMBL90469 0.84 MAPT (0.50) TSHRSMN1; SMN2ALOX15HTTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4562015-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME Cedilla Therapeutics, Inc. (US) 2025-06-04 EP disclosed
WO-2024026481-A2 CDK2 INHIBITORS AND METHODS OF USING THE SAME CEDILLA THERAPEUTICS, INC. (US) 2024-02-01 WO disclosed
CN-109836524-B Catalyst composition, ethylene-alpha-olefin polymer and preparation method thereof 中国石油天然气股份有限公司 2022-03-29 CN disclosed
US-20210161863-A1 PREPARATION AND USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN THE TREATMENT OF CONDITIONS AFFECTED BY MONOAMINE NEUROTRANSMITTERS MCKINNEY ANTHONY ALEXANDER (US) 2021-06-03 US disclosed
CN-105960402-B Microbicidal heterobicyclic derivatives 先正达参股股份有限公司 2019-06-28 CN disclosed
CN-109836524-A Catalyst composition, ethylene- α -olefin polymer and preparation method thereof 中国石油天然气股份有限公司 2019-06-04 CN disclosed
CN-109836523-A Catalyst composition, ethylene- α -olefin polymer and preparation method thereof 中国石油天然气股份有限公司 2019-06-04 CN disclosed
US-20180256542-A1 PREPARATION AND USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN THE TREATMENT OF CONDITIONS AFFECTED BY MONOAMINE NEUROTRANSMITTERS ETHISMOS RESEARCH, INC. 2018-09-13 US disclosed
CN-107954999-A Han oxadiazole rings compound, preparation method, intermediate, composition and application 上海医药集团股份有限公司 2018-04-24 CN disclosed
US-20160346249-A1 USE OF AMITIFADINE, (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN METHODS AND COMPOSITIONS WITH ENHANCED EFFICACY AND REDUCED METABOLIC SIDE EFFECTS AND TOXICITY FOR TREATMENT OF DEPRESSION AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS AND CONDITIONS AFFECTED BY MONOAMINE NEUROTRANSMITTERS ETHISMOS RESEARCH, INC. 2016-12-01 US disclosed
WO-2000058293-A2 GLUCOKINASE ACTIVATORS F. HOFFMANN-LA ROCHE AG (CH) 2000-10-05 WO disclosed
US-5965576-A Cyclic amide derivatives for treating asthma ZENECA LIMITED (GB) 1999-10-12 US disclosed
US-5705505-A Cyclic amide derivatives for treating asthma ZENECA LIMITED (GB) 1998-01-06 US disclosed
US-5589489-A Cyclic amide derivatives for treating asthma ZENECA LIMITED (GB) 1996-12-31 US disclosed
EP-0734383-A1 CYCLIC AMIDE DERIVATIVES AS NEUROKININ A ANTAGONISTS ZENECA LIMITED (GB) 1996-10-02 EP disclosed
WO-1995016682-A1 CYCLIC AMIDE DERIVATIVES AS NEUROKININ A ANTAGONISTS ZENECA LIMITED (GB) 1995-06-22 WO disclosed
US-4435419-A Method of treating depression using azabicyclohexanes AMERICAN CYANAMID COMPANY (US) 1984-03-06 US disclosed
US-4231935-A ANXIOLYTICS AND ANALGESICS AMERICAN CYANAMID COMPANY (US) 1980-11-04 US disclosed
US-4196120-A 1,2-BIS(HYDROCARBYLSULFONYLOXY OR HALO METHYL)CYCLOPROPYLBENZENE, OPTICAL ACITIVITY ANALGESICS AMERICAN CYANAMID COMPANY (US) 1980-04-01 US disclosed
US-4131611-A ANXIOLYTIC, ANALGESIC AMERICAN CYANAMID COMPANY (US) 1978-12-26 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210161863-A1 PREPARATION AND USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN THE TREATMENT OF CONDITIONS AFFECTED BY MONOAMINE NEUROTRANSMITTERS COMT, SLC6A3, HTR3A TSHR 1370/4885SMN1; SMN2 2457/4885ALOX15 992/4885
US-20160346249-A1 USE OF AMITIFADINE, (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN METHODS AND COMPOSITIONS WITH ENHANCED EFFICACY AND REDUCED METABOLIC SIDE EFFECTS AND TOXICITY FOR TREATMENT OF DEPRESSION AND OTHER CENTRAL NERVOUS SYSTEM DISORDERS AND CONDITIONS AFFECTED BY MONOAMINE NEUROTRANSMITTERS CYP2D6, MAOB, HTR1A TSHR 2280/4885SMN1; SMN2 1539/4885ALOX15 337/4885
US-20180256542-A1 PREPARATION AND USE OF (+)-1-(3,4-DICHLOROPHENYL)-3-AZABICYCLO[3.1.0]HEXANE IN THE TREATMENT OF CONDITIONS AFFECTED BY MONOAMINE NEUROTRANSMITTERS COMT, SLC6A3, HTR3A TSHR 1370/4885SMN1; SMN2 2457/4885ALOX15 992/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.