Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 16/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 16/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 16/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649439 | 0.88 | GABRG2 (0.44) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7079058 | 0.85 | GABRG2 (0.52) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2649504 | 0.80 | ALDH1A1 (0.45) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2650206 | 0.73 | ALDH1A1 (0.43) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2648091 | 0.73 | GABRA1 (0.48) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2658954 | 0.72 | GABRG2 (0.41) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2657570 | 0.72 | GABRG2 (0.53) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL7238799 | 0.71 | GABRG2 (0.41) | GABRG2GABRB3GABRA3GABRA1GABRA5 | |
| SCHEMBL2657618 | 0.71 | GABRG2 (0.52) | GABRG2GABRB3GABRA3GABRA1GABRA2 | |
| SCHEMBL2658148 | 0.68 | GSK3A (0.40) | GABRG2GABRB3GABRA3GABRA1GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6541484-B2 | Central nervous system disorders; psychological disorders | MERCK SHARP & DOHME LIMITED | 2003-04-01 | — | — | US | disclosed |
| US-20030004180-A1 | Pyrazolo-pyridine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-01-02 | — | — | US | disclosed |
| EP-1244659-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2002-10-02 | — | — | EP | disclosed |
| WO-2001044244-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030004180-A1 | Pyrazolo-pyridine derivatives as ligands for gaba receptors | GABRA3, GABRA4, GABRB3 | GABRG2 16/4885GABRB3 3/4885GABRA3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.