Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649291 | 0.87 | MAPT (0.50) | RAB9AMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2649991 | 0.83 | LMNA (0.46) | MAPTALDH1A1SMN1; SMN2LMNAPRKCZ | |
| SCHEMBL2649211 | 0.83 | RAB9A (0.43) | RAB9AGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2648348 | 0.82 | ALDH1A1 (0.47) | RAB9AGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2651383 | 0.80 | KDM4E (0.39) | GAAMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL6974946 | 0.73 | MAPT (0.40) | RAB9AGAAMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2649878 | 0.72 | ALDH1A1 (0.45) | GAAMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL2649623 | 0.72 | CNR2 (0.43) | RXFP1 | |
| SCHEMBL28362521 | 0.69 | KCNJ1 (0.64) | RAB9AGAAMAPTALDH1A1LMNA | |
| SCHEMBL6985104 | 0.68 | MAPT (0.38) | GAAMAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064283-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999048892-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-30 | — | — | WO | disclosed |