Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.44 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.44 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649285 | 0.87 | RAB9A (0.48) | MAPTALDH1A1RAB9AADORA3LMNA | |
| SCHEMBL2649211 | 0.81 | RAB9A (0.43) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL2649623 | 0.80 | CNR2 (0.43) | CYP1A2POLB | |
| SCHEMBL2649546 | 0.75 | HTT (0.44) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL2649991 | 0.75 | LMNA (0.46) | MAPTALDH1A1MEN1KMT2ACACNA1D | |
| SCHEMBL2648348 | 0.74 | ALDH1A1 (0.47) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL6974946 | 0.72 | MAPT (0.40) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL2651383 | 0.72 | KDM4E (0.39) | MAPTALDH1A1MAPK1KMT2ALMNA | |
| SCHEMBL2649878 | 0.71 | ALDH1A1 (0.45) | MAPTALDH1A1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2649630 | 0.70 | TDP1 (0.42) | MAPTALDH1A1MAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064283-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999048892-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-30 | — | — | WO | disclosed |