Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649623 | 0.86 | CNR2 (0.43) | FNTAFNTBELANEHRH2HRH1 | |
| SCHEMBL2649546 | 0.84 | HTT (0.44) | KDM4EALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL2649991 | 0.84 | LMNA (0.46) | ALDH1A1SMN1; SMN2L3MBTL1MAPTHPGD | |
| SCHEMBL2649211 | 0.84 | RAB9A (0.43) | KDM4EALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL2648348 | 0.83 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL2649285 | 0.80 | RAB9A (0.48) | ALDH1A1SMN1; SMN2L3MBTL1MAPTGAA | |
| SCHEMBL2649878 | 0.73 | ALDH1A1 (0.45) | KDM4EALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL2649291 | 0.72 | MAPT (0.50) | ALDH1A1SMN1; SMN2MAPTMAPK1NPSR1 | |
| SCHEMBL2649630 | 0.71 | TDP1 (0.42) | KDM4EALDH1A1SMN1; SMN2L3MBTL1MAPT | |
| SCHEMBL2997892 | 0.68 | CA12 (0.56) | KDM4EALDH1A1SMN1; SMN2FNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064283-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999048892-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-30 | — | — | WO | disclosed |