Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2649546 | 0.87 | HTT (0.44) | LMNATARBP2MAPTNPSR1ALDH1A1 | |
| SCHEMBL2649211 | 0.87 | RAB9A (0.43) | LMNAMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL2648348 | 0.86 | ALDH1A1 (0.47) | LMNATARBP2MAPTNPSR1ALDH1A1 | |
| SCHEMBL2651383 | 0.84 | KDM4E (0.39) | LMNAMAPTGABRA2NPSR1ALDH1A1 | |
| SCHEMBL2649285 | 0.83 | RAB9A (0.48) | LMNAMAPTPRKCZALDH1A1L3MBTL1 | |
| SCHEMBL2649878 | 0.76 | ALDH1A1 (0.45) | LMNAMAPTNPSR1ALDH1A1KMT2A | |
| SCHEMBL2649623 | 0.76 | CNR2 (0.43) | CYP1A2 | |
| SCHEMBL2649291 | 0.75 | MAPT (0.50) | LMNAMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL2649630 | 0.74 | TDP1 (0.42) | LMNAMAPTNPSR1ALDH1A1MEN1 | |
| SCHEMBL29812171 | 0.69 | PRKCZ (0.34) | MAPTPRKCZTRPM8NPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064283-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2001-01-03 | — | — | EP | disclosed |
| WO-1999048892-A1 | PYRAZOLO-PYRIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1999-09-30 | — | — | WO | disclosed |