Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702064 | 0.85 | ADRA2C (0.58) | ADRA2CKCNH2DRD2HTR1A | |
| SCHEMBL6151540 | 0.83 | MAPT (0.62) | ADRA2CDRD2HTR1AADORA2BHTR4 | |
| SCHEMBL1812286 | 0.83 | MAPT (0.62) | ADRA2CDRD2HTR1AADORA2BHTR4 | |
| SCHEMBL27468384 | 0.82 | ADRA2C (0.54) | ADRA2CKCNH2DRD2HTR1AADORA2B | |
| SCHEMBL8348977 | 0.82 | DRD2 (0.52) | KCNH2DRD2HTR1AMAPTTSHR | |
| SCHEMBL12287089 | 0.82 | GAA (0.50) | KCNH2DRD2HTR1AADORA2BHTR4 | |
| SCHEMBL16358911 | 0.81 | SIGMAR1 (0.49) | HTR4ALDH1A1MAPTTSHR | |
| SCHEMBL4577257 | 0.80 | DRD2 (0.50) | KCNH2DRD2HTR1AALDH1A1MAPT | |
| SCHEMBL28651152 | 0.80 | DRD2 (0.66) | ADRA2CKCNH2DRD2CYP2D6 | |
| SCHEMBL30774338 | 0.80 | ADRA2C (0.51) | ADRA2CKCNH2DRD2HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615896-B1 | NOVEL BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS | NEUROSEARCH AS (DK) | 2008-04-23 | — | — | EP | disclosed |
| US-20060241101-A1 | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds | NEUSEARCH A/S (DK) | 2006-10-26 | — | — | US | disclosed |
| EP-1615896-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS | NEUROSEARCH A/S (DK) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089912-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS | NEUROSEARCH A/S (DK) | 2004-10-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060241101-A1 | Novel benzimidazole derivatives and pharmaceutical compositions comprising these compounds | GABRA2, GABRA1, GABRA5 | ADRA2C 30/4885KCNH2 330/4885DRD2 1558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.