Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27737137 | 0.82 | ALDH1A1 (0.53) | ALDH1A1LMNARAB9AL3MBTL1MEN1 | |
| SCHEMBL3129377 | 0.78 | LMNA (0.59) | ALDH1A1LMNARAB9AL3MBTL1MEN1 | |
| SCHEMBL15581589 | 0.76 | GABRA5 (0.44) | ALDH1A1LMNARAB9AL3MBTL1MEN1 | |
| SCHEMBL2657920 | 0.76 | MEN1 (0.54) | ALDH1A1LMNAMEN1SMN1; SMN2MAPT | |
| SCHEMBL15110978 | 0.75 | — | — | |
| SCHEMBL2090920 | 0.74 | RAB9A (0.59) | ALDH1A1LMNARAB9AL3MBTL1MEN1 | |
| SCHEMBL2651752 | 0.74 | ALDH1A1 (0.51) | ALDH1A1LMNARAB9AL3MBTL1MEN1 | |
| SCHEMBL29444684 | 0.74 | ALDH1A1 (0.48) | ALDH1A1LMNARAB9AL3MBTL1MEN1 | |
| SCHEMBL14206861 | 0.72 | SLC6A3 (0.45) | ALDH1A1LMNARAB9AL3MBTL1MEN1 | |
| SCHEMBL972897 | 0.71 | ALDH1A1 (0.49) | ALDH1A1LMNARAB9AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003024964-A1 | TRICYCLIC PYRIDIN-2-ONE ANALOGUES AS GABA-A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 2003-03-27 | — | — | WO | disclosed |
| WO-2003016311-A1 | TRICYCLIC PYRIDIN-2-ONE ANALOGUES AS LIGANDS FOR GABA-A RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2003-02-27 | — | — | WO | disclosed |