Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | SI | P14410 | 2/20 | 0.56 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10749428 | 0.78 | MGAM (0.69) | MGAMGAASIMGAM2PKM | |
| SCHEMBL4873847 | 0.77 | KMO (0.49) | MGAMGAASIMGAM2PKM | |
| SCHEMBL6792255 | 0.74 | ALDH1A1 (0.51) | MGAMGAASIMGAM2PKM | |
| SCHEMBL2667905 | 0.73 | MAP4K4 (0.49) | GAAPKMRAB9AMAPTNPC1 | |
| SCHEMBL6738366 | 0.73 | TSHR (0.76) | MGAMGAASIMGAM2PKM | |
| SCHEMBL2311878 | 0.73 | MGAM (0.55) | MGAMGAASIMGAM2PKM | |
| SCHEMBL2082486 | 0.73 | RAB9A (0.50) | RAB9AMAPTNPC1ALDH1A1TDP1 | |
| SCHEMBL10339419 | 0.73 | MGAM (0.58) | MGAMGAASIMGAM2PKM | |
| SCHEMBL30461135 | 0.73 | RAB9A (0.69) | MGAMGAASIMGAM2PKM | |
| SCHEMBL30461136 | 0.73 | RAB9A (0.69) | MGAMGAASIMGAM2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7851490-B2 | Benzimidazole derivatives and their use for modulating the GABAA receptor complex | NEUROSEARCH A/S (DK) | 2010-12-14 | — | — | US | disclosed |
| US-7851490-B2 | Benzimidazole derivatives and their use for modulating the GABAA receptor complex | NEUROSEARCH A/S (DK) | 2010-12-14 | — | — | US | disclosed |
| US-7851490-B2 | Benzimidazole derivatives and their use for modulating the GABAA receptor complex | NEUROSEARCH A/S (DK) | 2010-12-14 | — | — | US | disclosed |
| EP-1877052-B1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH AS (DK) | 2009-07-22 | — | — | EP | disclosed |
| US-20090036493-A1 | Benzimidazole Derivatives and Their Use for Modulating the GABA Alpha Receptor Complex | ANIONA APS (DK) | 2009-02-05 | — | — | US | disclosed |
| US-20090036493-A1 | Benzimidazole Derivatives and Their Use for Modulating the GABA Alpha Receptor Complex | ANIONA APS (DK) | 2009-02-05 | — | — | US | disclosed |
| US-20090036493-A1 | Benzimidazole Derivatives and Their Use for Modulating the GABA Alpha Receptor Complex | ANIONA APS (DK) | 2009-02-05 | — | — | US | disclosed |
| CN-101141958-A | Benzimidazole derivatives and their use for modulating GABAAUse of receptor complexes | NEUROSEARCH AS (DK) | 2008-03-12 | — | — | CN | disclosed |
| EP-1877052-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2008-01-16 | — | — | EP | disclosed |
| WO-2006108800-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-10-19 | — | — | WO | disclosed |
| WO-2006108800-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX | NEUROSEARCH A/S (DK) | 2006-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036493-A1 | Benzimidazole Derivatives and Their Use for Modulating the GABA Alpha Receptor Complex | GABRB2, GABRB1, GABRB3 | MGAM 4385/4885GAA 739/4885SI 2204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.