Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.38 |
| ▸ | PNMT | P11086 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652516 | 0.81 | PNMT (0.36) | PNMTKDM1AALDH1A1MAPTKCNH2 | |
| SCHEMBL2654022 | 0.80 | AKR1C3 (0.38) | HRH4PNMTKDM1AAKR1C3AKR1C2 | |
| SCHEMBL2652981 | 0.77 | KMT2A (0.41) | PNMTKDM1AALDH1A1CLK1 | |
| SCHEMBL2652954 | 0.72 | PTGS2 (0.45) | HRH4PNMTKDM1AALDH1A1 | |
| SCHEMBL25442424 | 0.71 | HRH4 (0.47) | HRH4AKR1C3AKR1C2ALDH1A1ENPP2 | |
| SCHEMBL2652996 | 0.71 | PTGS2 (0.47) | HRH4PNMTKDM1ACLK1 | |
| SCHEMBL20526546 | 0.70 | G6PD (0.50) | HRH4AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL25442683 | 0.70 | HRH4 (0.43) | HRH4AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL8947263 | 0.70 | LMNA (0.51) | HRH4AKR1C3AKR1C2ALDH1A1 | |
| SCHEMBL13176065 | 0.67 | LMNA (0.44) | HRH4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |