Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.38 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652996 | 0.99 | PTGS2 (0.47) | PTGS2HRH4PNMTKDM1ASLC6A9 | |
| SCHEMBL2653857 | 0.84 | PNMT (0.37) | PTGS2HRH4PNMTPTGS1 | |
| SCHEMBL2652827 | 0.79 | PTGS2 (0.42) | PTGS2HRH4KDM1ASLC6A9KMT2A | |
| SCHEMBL2652981 | 0.79 | KMT2A (0.41) | PTGS2PNMTKDM1AKMT2AMEN1 | |
| SCHEMBL2653280 | 0.78 | PTGS2 (0.44) | PTGS2HRH4KDM1ASLC6A9KMT2A | |
| SCHEMBL2653085 | 0.76 | NAMPT (0.39) | ALDH1A1HTR6 | |
| SCHEMBL2655331 | 0.75 | HSP90AA1 (0.59) | PNMTALDH1A1 | |
| SCHEMBL2653810 | 0.75 | PTGDR2 (0.46) | — | |
| SCHEMBL2654132 | 0.75 | PTGS2 (0.41) | PTGS2HRH4SLC6A9KMT2AMEN1 | |
| SCHEMBL2652929 | 0.72 | HRH4 (0.38) | HRH4PNMTKDM1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |