Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 10/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655064 | 0.85 | NAMPT (0.41) | NAMPTJAK1TSHRLMNAHTT | |
| SCHEMBL2652954 | 0.76 | PTGS2 (0.45) | ALDH1A1HTR6 | |
| SCHEMBL2653857 | 0.76 | PNMT (0.37) | — | |
| SCHEMBL2652996 | 0.75 | PTGS2 (0.47) | — | |
| SCHEMBL2653153 | 0.71 | ALDH1A1 (0.54) | NAMPTTSHRLMNAHTTSMN1; SMN2 | |
| SCHEMBL1581787 | 0.69 | NAMPT (0.40) | NAMPTJAK1TSHRLMNAHTT | |
| SCHEMBL1581885 | 0.67 | TSHR (0.43) | NAMPTJAK1TSHRLMNAHTT | |
| SCHEMBL1581881 | 0.67 | TSHR (0.43) | NAMPTJAK1TSHRLMNAHTT | |
| SCHEMBL2655331 | 0.66 | HSP90AA1 (0.59) | L3MBTL1ALDH1A1 | |
| SCHEMBL2653810 | 0.66 | PTGDR2 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |