Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653280 | 0.99 | PTGS2 (0.44) | PTGS2SLC6A9CNR2KMT2AHRH4 | |
| SCHEMBL2654132 | 0.85 | PTGS2 (0.41) | PTGS2SLC6A9KMT2AHRH4MEN1 | |
| SCHEMBL2652798 | 0.85 | ALDH1A1 (0.42) | PTGS2KMT2ACYP3A4MEN1SLC6A2 | |
| SCHEMBL2652919 | 0.83 | CNR2 (0.36) | CNR2KMT2ACYP3A4LMNAALDH1A1 | |
| SCHEMBL2653267 | 0.81 | CA2 (0.38) | CNR2CYP3A4 | |
| SCHEMBL2652954 | 0.79 | PTGS2 (0.45) | PTGS2SLC6A9KMT2AHRH4KDM1A | |
| SCHEMBL2652996 | 0.78 | PTGS2 (0.47) | PTGS2SLC6A9KMT2AHRH4KDM1A | |
| SCHEMBL2653194 | 0.78 | CYP3A4 (0.39) | CYP3A4PTGDR | |
| SCHEMBL2652918 | 0.78 | KMT2A (0.43) | PTGS2CNR2KMT2AKDM1ACYP3A4 | |
| SCHEMBL2653490 | 0.77 | CYP3A4 (0.41) | KMT2ACYP3A4MEN1PTGDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |