Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 5/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652996 | 0.85 | PTGS2 (0.47) | PNMTPTGS2HRH4PTGS1 | |
| SCHEMBL2652954 | 0.84 | PTGS2 (0.45) | PNMTPTGS2HRH4PTGS1 | |
| SCHEMBL2652919 | 0.83 | CNR2 (0.36) | PNMTCNR2RORCPOLB | |
| SCHEMBL2653085 | 0.76 | NAMPT (0.39) | — | |
| SCHEMBL2655331 | 0.73 | HSP90AA1 (0.59) | PNMTPOLB | |
| SCHEMBL2653810 | 0.73 | PTGDR2 (0.46) | — | |
| SCHEMBL2653394 | 0.73 | PTGDR2 (0.50) | — | |
| SCHEMBL2653267 | 0.71 | CA2 (0.38) | CNR2POLBCTDSP1 | |
| SCHEMBL2652981 | 0.67 | KMT2A (0.41) | PNMTPTGS2RORCPTGS1 | |
| SCHEMBL2653280 | 0.66 | PTGS2 (0.44) | PTGS2CNR2HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |