Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655064 | 0.86 | NAMPT (0.41) | ALDH1A1PKMSMN1; SMN2LMNAHTT | |
| SCHEMBL2653863 | 0.77 | RAB9A (0.48) | ALDH1A1PKMSMN1; SMN2LMNAHTT | |
| SCHEMBL2652798 | 0.76 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2LMNAHTTMAPT | |
| SCHEMBL2652827 | 0.73 | PTGS2 (0.42) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2653280 | 0.72 | PTGS2 (0.44) | ALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL2652919 | 0.72 | CNR2 (0.36) | ALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL1581806 | 0.72 | SMN1; SMN2 (0.57) | ALDH1A1PKMSMN1; SMN2LMNAHTT | |
| SCHEMBL2653085 | 0.71 | NAMPT (0.39) | ALDH1A1PKMSMN1; SMN2LMNAHTT | |
| SCHEMBL1876581 | 0.71 | IDO1 (0.70) | SMN1; SMN2LMNAHTTTSHRNAMPT | |
| SCHEMBL2653267 | 0.70 | CA2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |