SCHEMBL26536740

SCHEMBL26536740

O=S(=O)(Nc1ccc(F)c(Cl)c1)c1ccc(OC(F)(F)F)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 2/20 0.60
MEN1 O00255 3/20 0.58
KMT2A Q03164 3/20 0.58
PKM P14618 2/20 0.58
ALDH1A1 P00352 2/20 0.58
LMNA P02545 2/20 0.58
TSHR P16473 1/20 0.58
NPSR1 Q6W5P4 1/20 0.58
GSK3B P49841 1/20 0.52
HSD17B3 P37058 1/20 0.51
HSD17B2 P37059 1/20 0.51
MAPT P10636 3/20 0.51
TP53 P04637 2/20 0.51
HDAC1 Q13547 3/20 0.51
HDAC8 Q9BY41 3/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
FBP1 P09467 1/20 0.51
HDAC3 O15379 2/20 0.49
HDAC4 P56524 2/20 0.49
HDAC7 Q8WUI4 2/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26536689 0.89 FFAR4 (0.63) FFAR4HSD17B3HSD17B2MAPTTP53
SCHEMBL7570765 0.85 CES1 (0.67) FFAR4ALDH1A1MAPTTP53HDAC1
SCHEMBL29561778 0.84 PGR (0.60) FFAR4MAPTTP53HDAC1HDAC8
SCHEMBL1472119 0.84 PGR (0.66) FFAR4MEN1KMT2APKMALDH1A1
SCHEMBL26536553 0.83 FFAR4 (0.73) FFAR4KMT2ATSHRMAPTTP53
SCHEMBL1472212 0.83 FFAR1 (0.64) FFAR4MEN1KMT2APKMALDH1A1
SCHEMBL14458175 0.83 ALOX15 (0.64) FFAR4MEN1KMT2APKMALDH1A1
SCHEMBL29839161 0.82 L3MBTL1 (0.49) FFAR4ALDH1A1LMNAGSK3BFBP1
SCHEMBL26920383 0.82 L3MBTL1 (0.49) FFAR4ALDH1A1LMNAGSK3BFBP1
SCHEMBL7570513 0.80 FFAR4 (0.64) FFAR4ALDH1A1GSK3BMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230322715-A1 BROAD SPECTRUM ANTI-CANCER COMPOUNDS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-10-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230322715-A1 BROAD SPECTRUM ANTI-CANCER COMPOUNDS YTHDF1, YTHDF3, YTHDF2 FFAR4 2391/4885MEN1 3143/4885KMT2A 134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.